Superiority of Ticagrelor Over Clopidogrel in Patients After Cardiac Arrest Undergoing Therapeutic Hypothermia

被引：24

作者：

Moudgil, Rohit ^{[1
]}

Al-Turbak, Haytham ^{[1
]}

Osborne, Christina ^{[1
]}

Hibbert, Benjamin ^{[1
]}

So, Derek Y. F. ^{[1
]}

Le May, Michel R. ^{[1
]}

机构：

[1] Univ Ottawa, Inst Heart, Dept Med, Div Cardiol, Ottawa, ON K1Y 4W7, Canada

来源：

CANADIAN JOURNAL OF CARDIOLOGY | 2014年 / 30卷 / 11期

关键词：

PERCUTANEOUS CORONARY INTERVENTION; ANTIPLATELET THERAPY; STENT THROMBOSIS; REGISTRY; TRIAL;

D O I：

10.1016/j.cjca.2014.07.745

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Current guidelines suggest that patients undergoing percutaneous coronary intervention (PCI) receive dual-antiplatelet therapy. There are limited data on the pharmacodynamics of P2Y12 inhibitors in patients with cardiac arrest and return of spontaneous circulation (ROSC) undergoing PCI and therapeutic hypothermia (TH). Accordingly, we compared inhibition of platelet reactivity in patients undergoing TH receiving clopidogrel or ticagrelor. Notably, clopidogrel was ineffective in lowering platelet reactivity, with ticagrelor providing a more rapid (within 4 hours) and sustained reduction (6 days) in platelet reactivity. Pending outcome-based studies, ticagrelor should be used preferentially in patients who have ROSC and are undergoing PCI and TH.

引用

页码：1396 / 1399

页数：4

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