Implantable Neural Probes for Chronic Electrical Recording and Optical Stimulation

被引:0
|
作者
Wu, Fan [1 ]
Stark, Eran [2 ]
Im, Maesoon [1 ,3 ]
Cho, Il-Joo [1 ,4 ]
Tien, Lee [5 ]
Chen, Fujun [6 ]
Yoon, Eui-Sung [4 ]
Buzsaki, Gyorgi [2 ]
Kaplan, David [5 ]
Berke, Josh [6 ]
Wise, Kensall D. [1 ]
Yoon, Euisik [1 ]
机构
[1] Univ Michigan, Dept Elect Engn & Comp Sci, Ann Arbor, MI 48109 USA
[2] NYU, Neurosci Inst, New York, NY 10016 USA
[3] Massachusetts Gen Hosp, Harvard Med Sch, Dept Neurosurg, Boston, MA 02114 USA
[4] Korea Inst Sci & Technol, Brain Sci Inst, Ctr BioMicrosyst, Seoul 136791, South Korea
[5] Tufts Univ, Dept Biomed Engn, Medford, MA USA
[6] Univ Michigan, Dept Psychol, Ann Arbor, MI USA
关键词
BRAIN;
D O I
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中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
In order to advance the understanding of brain functions, it is critical to manipulate and monitor the neural circuitry in the cellular level. Supporting optogenetics, silicon probes with monolithically integrated waveguides and electrodes were designed and validated with in-vivo recording of photo-induced neural activity. For chronic applications, we developed a technology that utilizes a biodegradable silk coating to support probes with unique geometries and flexibility for reduced tissue reactions. Consistent recording has been observed for 5 weeks in rats.
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页数:4
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