Biomimetic Approaches Towards the Synthesis of Complex Dimeric Natural Products

被引：10
|
作者：
Stanley, Paul A. [1 ]
Spiteri, Christian [1 ]
Moore, Jonathan C. [1 ]
Barrow, Andrew S. [1 ]
Sharma, Pallavi [2 ]
Moses, John E. [1 ]
机构：
[1] Univ Nottingham, Sch Chem, Univ Pk, Nottingham NG7 2RD, England
[2] Lincoln Univ, Joseph Banks Labs, Sch Chem, Lincoln LN6 7DL, England
来源：
CURRENT PHARMACEUTICAL DESIGN | 2016年 / 22卷 / 12期
基金：
英国工程与自然科学研究理事会;
关键词：
Biomimetic; dimer; natural product; total synthesis; ENANTIOSELECTIVE TOTAL-SYNTHESIS; ENDIANDRIC ACID CASCADE; STEREOCONTROLLED TOTAL-SYNTHESIS; EPOXYQUINOL-A; ORGANIC-SYNTHESIS; ANGIOGENESIS INHIBITOR; FUNGAL METABOLITE; EPOXYTWINOL-A; ELECTROCYCLIZATIONS; KINGIANIN;
D O I：
10.2174/1381612822666160101123106
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We present a selection of elegant and diverse biomimetic syntheses of complex natural product dimers. The dimerisation pathways discussed encompass the most prevalent strategies, including: Diels-Alder, Aldol, Mannich, conjugate addition, oxidative, radical and photochemical approaches; each underpinned through rational biosynthetic speculation.
引用
收藏
页码：1628 / 1657
页数：30
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