Synthesis of biologically active N2-amine adducts of 2′-deoxyguanosine

被引：26

作者：

Bonala, RR ^{[1
]}

Shishkina, IG ^{[1
]}

Johnson, F ^{[1
]}

机构：

[1] SUNY Stony Brook, Dept Pharmacol Sci, Stony Brook, NY 11794 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 38期

基金：

美国国家卫生研究院;

关键词：

2 '-deoxyguanosine; N-2-adducts; Buchwald-Hartwig reaction;

D O I：

10.1016/S0040-4039(00)01196-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several biologically important N-2-adducts of 2'-deoxyguanosine (dG) that previously were difficultly accessible, have been synthesized directly by means of the Buchwald-Hartwig reaction. The reaction employed in each case involves the coupling of 2'-deoxy-2-bromoinosine with the appropriate amine. Deprotection in all cases gave good yields of the desired 2-alkylated or -arylated deoxynucleoside. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：7281 / 7284

页数：4

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