New candidate virus in association with Hodgkin's disease

被引：13
作者：
Benharroch, D
Shemer-Avni, Y
Levy, A
Myint, YY
Ariad, S
Rager, B
Sacks, M
Gopas, J
机构：
[1] Soroka Univ Med Ctr, Dept Pathol, IL-84101 Beer Sheva, Israel
[2] Ben Gurion Univ Negev, Fac Hlth Sci, Dept Virol, IL-84105 Beer Sheva, Israel
[3] Ben Gurion Univ Negev, Fac Hlth Sci, Dept Epidemiol, Beer Sheva, Israel
[4] Soroka Univ Med Ctr, Dept Oncol, Beer Sheva, Israel
[5] Ben Gurion Univ Negev, Fac Hlth Sci, Dept Immunol, Beer Sheva, Israel
[6] Ben Gurion Univ Negev, Fac Hlth Sci, Dept Microbiol, Beer Sheva, Israel
来源：
LEUKEMIA & LYMPHOMA | 2003年 / 44卷 / 04期
关键词：
Hodgkin's disease; Epstein-Barr virus; measles virus; young adults;
D O I：
10.1080/1042819021000037994
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Epidemiologic and molecular investigations of Hodgkin's disease (HD) suggest a strong infectious association. The Epstein-Barr virus (EBV), together with its viral proteins, is expressed in Hodgkin-Reed-Sternberg (HRS) cells in the lymph nodes involved by HD. EBV is more likely to be related to childhood and older adult cases of HD and is much less frequently expressed in young adult HD patients, the group most expected to be associated with an infectious agent. In addition, the "hit and run" theory of EBV infection remains speculative and no other lymphotropic viruses studied to date seem to satisfy the quest for a new candidate virus in young adults with HD. We have recently found preliminary evidence suggesting a possible association between the measles virus (MV) and HD. This evidence is the subject of the present review.
引用
收藏
页码：605 / 610
页数：6
相关论文
共 51 条
  • [1] Hodgkin's disease in a national and hospital population: Trends over 20 years
    Abrahamsen, AF
    Egeland, T
    Hansen, S
    Langholm, R
    Holte, H
    Kvaloy, S
    [J]. EUROPEAN JOURNAL OF CANCER, 1997, 33 (14) : 2380 - 2383
  • [2] Risk factors for Hodgkin's disease by Epstein-Barr virus (EBV) status: Prior infection by EBV and other agents
    Alexander F.E.
    Jarrett R.F.
    Lawrence D.
    Armstrong A.A.
    Freeland J.
    Gokhale D.A.
    Kane E.
    Taylor G.M.
    Wright D.H.
    Cartwright R.A.
    [J]. British Journal of Cancer, 2000, 82 (5) : 1117 - 1121
  • [3] [Anonymous], 2001, FIELDS VIROLOGY
  • [4] Lack of involvement of known oncogenic DNA viruses in Epstein-Barr virus-negative Hodgkin's disease
    Armstrong, AA
    Shield, L
    Gallagher, A
    Jarrett, RF
    [J]. BRITISH JOURNAL OF CANCER, 1998, 77 (07) : 1045 - 1047
  • [5] Measles virus infection in rhesus macaques: Altered immune responses and comparison of the virulence of six different virus strains
    Auwaerter, PG
    Rota, PA
    Elkins, WR
    Adams, RJ
    DeLozier, T
    Shi, YQ
    Bellini, WJ
    Murphy, BR
    Griffin, DE
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1999, 180 (04) : 950 - 958
  • [6] Measles virus infection of thymic epithelium in the SCID-hu mouse leads to thymocyte apoptosis
    Auwaerter, PG
    Kaneshima, H
    McCune, JM
    Wiegand, G
    Griffin, DE
    [J]. JOURNAL OF VIROLOGY, 1996, 70 (06) : 3734 - 3740
  • [7] Benharroch D, 1997, INT J CANCER, V71, P138
  • [8] BENHARROCH D, 2001, LEUKEMIA LYMPHOMA S2, V42, P33
  • [9] Absence of a directly causative role for human herpesvirus 7 in human lymphoma and a review of human herpesvirus 6 in human malignancy
    Berneman, ZN
    Torelli, G
    Luppi, M
    Jarrett, RF
    [J]. ANNALS OF HEMATOLOGY, 1998, 77 (06) : 275 - 278
  • [10] CHARACTERIZATION OF MEASLES POLYPEPTIDES BY MONOCLONAL-ANTIBODIES
    BIRRER, MJ
    BLOOM, BR
    UDEM, S
    [J]. VIROLOGY, 1981, 108 (02) : 381 - 390
123456