Synthesis and antimicrobial activity of 2,10-dichloro-6-substituted amino acid ester-12H-dibenzo[d,g][1,3,2]dioxaphosphocin-6-oxides

被引：0

作者：

Kumar, B. S. ^{[2
]}

Reddy, M. V. N. ^{[1
]}

Reddy, G. C. S. ^{[1
]}

Krishna, A. B. ^{[1
]}

Reddy, C. S. ^{[1
]}

机构：

[1] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India

[2] Shizuoka Univ, Dept Nanomat, Grad Sch Sci & Technol, Hamamatsu, Shizuoka 4328561, Japan

来源：

BULGARIAN CHEMICAL COMMUNICATIONS | 2009年 / 41卷 / 04期

关键词：

Dioxaphosphocin-6-oxides; amino acid esters; spectral studies; antimicrobial activity; HUMAN-IMMUNODEFICIENCY-VIRUS; ANTI-HIV EFFICACY; PHOSPHORAMIDATE DERIVATIVES; D4T; INHIBITORS; INVITRO;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new class of 2,10-dichloro-6-substituted amino acid ester-12H-dibenzo[d,g][1,3,2]dioxaphosphocin-6-oxides have been synthesized in good yields via the condensation of 2,10-dichloro-6-chloro-12H-dibenzo[d,g][1,3,2]dioxaphosphocin with various amino acid esters in the presence of triethylamine. The title compounds were characterized by elemental analysis, IRS, NMR (H-1, C-13 and P-31) and mass spectral studies and found to exhibit moderate antimicrobial activity.

引用

页码：422 / 426

页数：5

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