An aggregation-induced emission-based pH-sensitive fluorescent probe for intracellular acidity sensing

被引：20

作者：

Lin, Na ^{[1
]}

Chen, Xiaohong ^{[2
]}

Yan, Shuanghong ^{[1
]}

Wang, Han ^{[2
]}

Lu, Zhixiang ^{[1
]}

Xia, Xin ^{[1
]}

Liang, Mengyu ^{[1
]}

Wu, Yun-Long ^{[2
]}

Zheng, Liyan ^{[1
]}

Cao, Qiue ^{[1
]}

Ding, Zhongtao ^{[1
]}

机构：

[1] Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Yunnan, Peoples R China

[2] Xiamen Univ, Sch Pharmaceut Sci, Xiamen, Fujian, Peoples R China

来源：

RSC ADVANCES | 2016年 / 6卷 / 30期

基金：

中国国家自然科学基金;

关键词：

LIGHT-UP PROBE; GRAPHENE OXIDE; CELLS; NANOCLUSTERS; APOPTOSIS; FLUOROGEN; STRATEGY; SENSOR; RANGE;

D O I：

10.1039/c6ra01167e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A dual-emission pH-sensitive fluorescent probe was developed, which displays green fluorescence in alkaline after deprotonation, while orange emission in acid at aggregated state. This novel probe allows the specific light-on in acidic lysosomes of cancer cells and tumors in nude mice, which indicates its potential application in cancer diagnosis.

引用

页码：25416 / 25419

页数：4

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