An aggregation-induced emission-based pH-sensitive fluorescent probe for intracellular acidity sensing

被引：20
|
作者：
Lin, Na [1 ]
Chen, Xiaohong [2 ]
Yan, Shuanghong [1 ]
Wang, Han [2 ]
Lu, Zhixiang [1 ]
Xia, Xin [1 ]
Liang, Mengyu [1 ]
Wu, Yun-Long [2 ]
Zheng, Liyan [1 ]
Cao, Qiue [1 ]
Ding, Zhongtao [1 ]
机构：
[1] Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Yunnan, Peoples R China
[2] Xiamen Univ, Sch Pharmaceut Sci, Xiamen, Fujian, Peoples R China
来源：
RSC ADVANCES | 2016年 / 6卷 / 30期
基金：
中国国家自然科学基金;
关键词：
LIGHT-UP PROBE; GRAPHENE OXIDE; CELLS; NANOCLUSTERS; APOPTOSIS; FLUOROGEN; STRATEGY; SENSOR; RANGE;
D O I：
10.1039/c6ra01167e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A dual-emission pH-sensitive fluorescent probe was developed, which displays green fluorescence in alkaline after deprotonation, while orange emission in acid at aggregated state. This novel probe allows the specific light-on in acidic lysosomes of cancer cells and tumors in nude mice, which indicates its potential application in cancer diagnosis.
引用
收藏
页码：25416 / 25419
页数：4
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