Puzzling Out Synaptic Vesicle 2 Family Members Functions

被引：80

作者：

Bartholome, Odile ^{[1
]}

Van den Ackerveken, Priscilla ^{[1
]}

Gil, Judit Sanchez ^{[1
]}

Bonardeaux, Orianne de la Brassinne ^{[1
]}

Leprince, Pierre ^{[1
]}

Franzen, Rachelle ^{[1
]}

Rogister, Bernard ^{[1
,2
]}

机构：

[1] Univ Liege, GIGA Neurosci, Lab Nervous Syst Disorders & Therapy, Liege, Belgium

[2] Univ Liege, Ctr Hosp Univ Liege CHU, Dept Neurol, Liege, Belgium

来源：

FRONTIERS IN MOLECULAR NEUROSCIENCE | 2017年 / 10卷

关键词：

SV2; protein; functions; neurotransmission; epilepsy; neurological diseases; KERATAN SULFATE PROTEOGLYCAN; SUGAR-TRANSPORT REGULATION; ENDOCYTIC SORTING ADAPTER; GUINEA-PIG HIPPOCAMPUS; 7S SNARE COMPLEXES; PROTEIN; 2A; ALZHEIMERS-DISEASE; NEUROTRANSMITTER RELEASE; BOTULINUM NEUROTOXIN; MESSENGER-RNA;

D O I：

10.3389/fnmol.2017.00148

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Synaptic vesicle proteins 2 (SV2) were discovered in the early 80s, but the clear demonstration that SV2A is the target of efficacious anti- epileptic drugs from the racetam family stimulated efforts to improve understanding of its role in the brain. Many functions have been suggested for SV2 proteins including ions or neurotransmitters transport or priming of SVs. Moreover, several recent studies highlighted the link between SV2 and different neuronal disorders such as epilepsy, Schizophrenia (SCZ), Alzheimer's or Parkinson's disease. In this review article, we will summarize our present knowledge on SV2A function(s) and its potential role(s) in the pathophysiology of various brain disorders.

引用

页数：15

共 130 条

[61] Molecular determinants of sugar transport regulation by ATP
Levine, KB
Cloherty, EK
Hamill, S
Carruthers, A
[J]. BIOCHEMISTRY, 2002, 41 (42) : 12629 - 12638
[62] Structural and physiologic determinants of human erythrocyte sugar transport regulation by adenosine triphosphate
Levine, KB
Cloherty, EK
Fidyk, NJ
Carruthers, A
[J]. BIOCHEMISTRY, 1998, 37 (35) : 12221 - 12232
[63] SV2A and SV2C are not vesicular Ca2+ transporters but control glucose-evoked granule recruitment
Lezzi, M
Theander, S
Janz, R
Loze, C
Wollheim, CB
[J]. JOURNAL OF CELL SCIENCE, 2005, 118 (23) : 5647 - 5660
[64] Synaptic function modulated by changes in the ratio of synaptotagmin I and IV
Littleton, JT
Serano, TL
Rubin, GM
Ganetzky, B
Chapman, ER
[J]. NATURE, 1999, 400 (6746) : 757 - 760
[65] Synaptic Vesicle Glycoprotein 2A Ligands in the Treatment of Epilepsy and Beyond
Loescher, Wolfgang
Gillard, Michel
Sands, Zara A.
Kaminski, Rafal M.
Klitgaard, Henrik
[J]. CNS DRUGS, 2016, 30 (11) : 1055 - 1077
[66] The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam
Lynch, BA
Lambeng, N
Nocka, K
Kensel-Hammes, P
Bajjalieh, SM
Matagne, A
Fuks, B
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (26) : 9861 - 9866
[67] Visualization of SV2A conformations in situ by the use of Protein Tomography
Lynch, Berkley A.
Matagne, Alain
Braennstrom, Annika
von Euler, Anne
Jansson, Magnus
Hauzenberger, Elenor
Soederhaell, J. Arvid
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 375 (04) : 491 - 495
[68] The Human Synaptic Vesicle Protein, SV2A, Functions as a Galactose Transporter in Saccharomyces cerevisiae
Madeo, Marianna
Kovacs, Attila D.
Pearce, David A.
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (48) : 33066 - 33071
[69] Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons
Magee, JC
Cook, EP
[J]. NATURE NEUROSCIENCE, 2000, 3 (09) : 895 - 903
[70] Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1
Mahrhold, Stefan
Bergstrom, Tomas
Stern, Daniel
Dorner, Brigitte G.
Astot, Crister
Rummel, Andreas
[J]. BIOCHEMICAL JOURNAL, 2016, 473 : 2645 - 2654

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