Puzzling Out Synaptic Vesicle 2 Family Members Functions

被引：80
作者：
Bartholome, Odile [1 ]
Van den Ackerveken, Priscilla [1 ]
Gil, Judit Sanchez [1 ]
Bonardeaux, Orianne de la Brassinne [1 ]
Leprince, Pierre [1 ]
Franzen, Rachelle [1 ]
Rogister, Bernard [1 ,2 ]
机构：
[1] Univ Liege, GIGA Neurosci, Lab Nervous Syst Disorders & Therapy, Liege, Belgium
[2] Univ Liege, Ctr Hosp Univ Liege CHU, Dept Neurol, Liege, Belgium
来源：
FRONTIERS IN MOLECULAR NEUROSCIENCE | 2017年 / 10卷
关键词：
SV2; protein; functions; neurotransmission; epilepsy; neurological diseases; KERATAN SULFATE PROTEOGLYCAN; SUGAR-TRANSPORT REGULATION; ENDOCYTIC SORTING ADAPTER; GUINEA-PIG HIPPOCAMPUS; 7S SNARE COMPLEXES; PROTEIN; 2A; ALZHEIMERS-DISEASE; NEUROTRANSMITTER RELEASE; BOTULINUM NEUROTOXIN; MESSENGER-RNA;
D O I：
10.3389/fnmol.2017.00148
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Synaptic vesicle proteins 2 (SV2) were discovered in the early 80s, but the clear demonstration that SV2A is the target of efficacious anti- epileptic drugs from the racetam family stimulated efforts to improve understanding of its role in the brain. Many functions have been suggested for SV2 proteins including ions or neurotransmitters transport or priming of SVs. Moreover, several recent studies highlighted the link between SV2 and different neuronal disorders such as epilepsy, Schizophrenia (SCZ), Alzheimer's or Parkinson's disease. In this review article, we will summarize our present knowledge on SV2A function(s) and its potential role(s) in the pathophysiology of various brain disorders.
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页数：15
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