COVID-19: The therapeutic landscape

被引:17
作者
Paules, Catharine, I [1 ]
Fauci, Anthony S. [2 ]
机构
[1] Penn State Hlth Milton S Hershey Med Ctr, Infect Dis, Hershey, PA 17033 USA
[2] NIAID, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
来源
MED | 2021年 / 2卷 / 05期
基金
美国国家卫生研究院;
关键词
SARS-COV-2;
D O I
10.1016/j.medj.2021.04.015
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Therapeutics for hospitalized COVID-19 patients were identified through a robust research response with several lessons learned: clinical trial data should guide therapeutic use, results should not be extrapolated between disease stages, and robust studies should be designed to give clinically relevant data. These lessons should be applied to the outpatient research response.
引用
收藏
页码:493 / +
页数:6
相关论文
共 15 条
  • [1] Remdesivir for the Treatment of Covid-19-Final Report
    Beigel, John H.
    Tomashek, Kay M.
    Dodd, Lori E.
    Mehta, Aneesh K.
    Zingman, Barry S.
    Kalil, Andre C.
    Hohmann, Elizabeth
    Chu, Helen Y.
    Luetkemeyer, Annie
    Kline, Susan
    de Castilla, Diego Lopez
    Finberg, Robert W.
    Dierberg, Kerry
    Tapson, Victor
    Hsieh, Lanny
    Patterson, Thomas F.
    Paredes, Roger
    Sweeney, Daniel A.
    Short, William R.
    Touloumi, Giota
    Lye, David Chien
    Ohmagari, Norio
    Oh, Myoung-don
    Ruiz-Palacios, Guillermo M.
    Benfield, Thomas
    Faetkenheuer, Gerd
    Kortepeter, Mark G.
    Atmar, Robert L.
    Creech, C. Buddy
    Lundgren, Jens
    Babiker, Abdel G.
    Pett, Sarah
    Neaton, James D.
    Burgess, Timothy H.
    Bonnett, Tyler
    Green, Michelle
    Makowski, Mat
    Osinusi, Anu
    Nayak, Seema
    Lane, H. Clifford
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (19) : 1813 - 1826
  • [2] Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
    Blanco-Melo, Daniel
    Nilsson-Payant, Benjamin E.
    Liu, Wen-Chun
    Uhl, Skyler
    Hoagland, Daisy
    Moller, Rasmus
    Jordan, Tristan X.
    Oishi, Kohei
    Panis, Maryline
    Sachs, David
    Wang, Taia T.
    Schwartz, Robert E.
    Lim, Jean K.
    Albrecht, Randy A.
    tenOever, Benjamin R.
    [J]. CELL, 2020, 181 (05) : 1036 - +
  • [3] Centers for Disease Control and Prevention, COVID-19: people with certain medical conditions
  • [4] Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry
    Gianfrancesco, Milena
    Hyrich, Kimme L.
    Al-Adely, Sarah
    Carmona, Loreto
    Danila, Maria, I
    Gossec, Laure
    Izadi, Zara
    Jacobsohn, Lindsay
    Katz, Patricia
    Lawson-Tovey, Saskia
    Mateus, Elsa F.
    Rush, Stephanie
    Schmajuk, Gabriela
    Simard, Julia
    Strangfeld, Anja
    Trupin, Laura
    Wysham, Katherine D.
    Bhana, Suleman
    Costello, Wendy
    Grainger, Rebecca
    Hausmann, Jonathan S.
    Liew, Jean W.
    Sirotich, Emily
    Sufka, Paul
    Wallace, Zachary S.
    Yazdany, Jinoos
    Machado, Pedro M.
    Robinson, Philip C.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2020, 79 (07) : 859 - 866
  • [5] Mechanisms of SARS-CoV-2 Transmission and Pathogenesis
    Harrison, Andrew G.
    Lin, Tao
    Wang, Penghua
    [J]. TRENDS IN IMMUNOLOGY, 2020, 41 (12) : 1100 - 1115
  • [6] Horby P, 2021, NEW ENGL J MED, V384, P693, DOI [10.1056/NEJMoa2021436, 10.1056/NEJMoa2022926]
  • [7] Characteristics of SARS-CoV-2 and COVID-19
    Hu, Ben
    Guo, Hua
    Zhou, Peng
    Shi, Zheng-Li
    [J]. NATURE REVIEWS MICROBIOLOGY, 2021, 19 (03) : 141 - 154
  • [8] Infectious Diseases Society of America, IDSA GUID TREATM MAN
  • [9] Johns Hopkins University of Medicine, COR RES CTR MORT AN
  • [10] Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19
    Kalil, A. C.
    Patterson, T. F.
    Mehta, A. K.
    Tomashek, K. M.
    Wolfe, C. R.
    Ghazaryan, V.
    Marconi, V. C.
    Ruiz-Palacios, G. M.
    Hsieh, L.
    Kline, S.
    Tapson, V.
    Iovine, N. M.
    Jain, M. K.
    Sweeney, D. A.
    El Sahly, H. M.
    Branche, A. R.
    Pineda, J. Regalado
    Lye, D. C.
    Sandkovsky, U.
    Luetkemeyer, A. F.
    Cohen, S. H.
    Finberg, R. W.
    Jackson, P. E. H.
    Taiwo, B.
    Paules, C. I.
    Arguinchona, H.
    Erdmann, N.
    Ahuja, N.
    Frank, M.
    Oh, M.
    Kim, E. -S.
    Tan, S. Y.
    Mularski, R. A.
    Nielsen, H.
    Ponce, P. O.
    Taylor, B. S.
    Larson, L. A.
    Rouphael, N. G.
    Saklawi, Y.
    Cantos, V. D.
    Ko, E. R.
    Engemann, J. J.
    Amin, A. N.
    Watanabe, M.
    Billings, J.
    Elie, M. -C.
    Davey, R. T.
    Burgess, T. H.
    Ferreira, J.
    Green, M.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (09) : 795 - 807