The prognostic value of the frontal QRS-T angle is comparable to cardiovascular autonomic neuropathy regarding long-term mortality in people with diabetes. A population based study

Cardiovascular autonomic neuropathy (CAN) is a well known prognostic marker in diabetes. A large angle between the QRS- and the T-wave vector (QRS-T angle) in the electrocardiogram (ECG) has recently been introduced as another marker of poor prognosis. Aim: To assess and compare the long-term predictive power of the frontal plane QRS-T angle with CAN in people with diabetes. Methods: In 1992-93 people with diabetes in the municipality of Horsens, Denmark, were identified by the prescription method and an age and gender stratified sample of 240 individuals with diabetes were randomly selected. The presence of CAN was defined using the heart rate response to Valsalva manoeuvre. The QRS-T angle was read using the method described by Gandhi. In July 2015 vital statistics were obtained from the Danish Civil Registration System. Results: 178 individuals accepted to participate in the study, of which 153 (86%) completed the Valsalva manoeuvre and had sinus rhythm. Total observation time was 21.5 (0.18) years, in which 99 (65%) individuals died. An elevated QRS-T angle and the presence of cardiovascular autonomic neuropathy were both found to be significant predictors of death. In Cox regression analyses, adjusting for the effect of gender, age, duration of diabetes, BMI, total-cholesterol, diabetes type, haemoglobin A1c, smoking status, hypertension and previous MI, an independent prognostic value was found for the QRS-T angle as well as the Valsalva ratio. Conclusion: A large QRS-T angle and the presence of cardiovascular autonomic neuropathy are both strong and independent long-term predictors of all-cause mortality in people with diabetes. (C) 2018 Published by Elsevier B.V.