Choroidal Thickness Change in Central Serous Chorioretinopathy after Photodynamic Therapy Using Optical Coherence Tomography

Objective: This study aimed to evaluate the change in choroidal thickness and subanalyze Haller's and Sattler' layer in patients with central serous chorioretinopathy (CSC) following low-fluence photodynamic therapy (PDT) using enhanced depth imaging optical coherence tomography (EDI-OCT). Methods: In this retrospective study, medical records of the patients with CSC were reviewed. Patients with a diagnosis of CSC and a history of decreased visual acuity for more than six months and treated with half-dose PDT with verteporfin were included in the study. Patients who received previous PDT for chronic CSC or had evidence of choroidal neovascular membrane were excluded. Main outcome measures were the change in choroidal thickness and subanalysis of Haller and Sattler layer after treatment. Results: A total of 13 eyes of 13 patients were included in the study. The mean age of the patients was 49 +/- 11 years (range 40-68). The mean subfoveal choroidal thickness decreased significantly from 310.60 +/- 89.16 mu m at baseline to 308.41 +/- 90.03 mu m after PDT (p<0.05). The mean Haller's layer thickness decreased significantly from 203.40 +/- 86.37 mu m to 200.20 +/- 81.55 mu m (p<0.05). The thickness of Sattler' layers did not differ significantly after PDT treatment (p>0.05). Conclusion: Half-fluence PDT for CSC resulted in thinner subfoveal choroidal thickness after PDT treatment. Sattler's layer had similar thickness in eyes with active CSC and after PDT. This study finding suggested that subfoveal choroidal thickness changes after half-dose PDT were likely due to the changes in Haller's layer.