Proprotein convertase furin/PCSK3 and atherosclerosis: New insights and potential therapeutic targets

被引：35
作者：
Ren, Kun [1 ,2 ]
Jiang, Ting [1 ]
Zheng, Xi-Long [3 ]
Zhao, Guo-Jun [1 ]
机构：
[1] Guilin Med Univ, Dept Histol & Embryol, Guilin 541004, Guangxi, Peoples R China
[2] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Peoples R China
[3] Univ Calgary, Dept Biochem & Mol Biol, Libin Cardiovasc Inst Alberta, Hlth Sci Ctr, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada
来源：
ATHEROSCLEROSIS | 2017年 / 262卷
基金：
中国博士后科学基金;
关键词：
Furin; Atherosclerosis; Lipid metabolism; Inflammation; SMOOTH-MUSCLE-CELLS; EPITHELIAL SODIUM-CHANNEL; MATRIX-METALLOPROTEINASE; BLOOD-PRESSURE; TGF-BETA; ENDOTHELIAL LIPASE; FURIN CLEAVAGE; IGF-I; RECEPTOR; GROWTH;
D O I：
10.1016/j.atherosclerosis.2017.04.005
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Furin, a member of the mammalian proprotein convertases family, can promote the proteolytic maturation of proproteins. It is known that furin is predominantly present in certain cell types of human atherosclerotic lesions and neointima in animal models, including vascular smooth muscle cells, endothelial cells and mononuclear inflammatory cells. Evidence suggests that furin participates in the initiation and progression of atherosclerosis through regulation of lipid and cholesterol metabolism, inflammatory response, blood pressure and the formation of atherosclerotic lesions. This review provides a panorama of the roles of furin in atherosclerosis and the insights into the prevention and treatment of atherosclerosis and cardiovascular disease. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：163 / 170
页数：8
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