Pneumococcal Surface Proteins as Virulence Factors, Immunogens, and Conserved Vaccine Targets

被引：30

作者：

Aceil, Javid ^{[1
]}

Avci, Fikri Y. ^{[1
]}

机构：

[1] Univ Georgia, Ctr Mol Med, Dept Biochem & Mol Biol, Athens, GA 30602 USA

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2022年 / 12卷

关键词：

Streptoccoccus pneumoniae; PspA; pneumolysin (PLY); PsrP; PhtD pneumococcal histidine triad protein D; conjugate vaccine; pneumococcal protein vaccine; CbpA; CHOLINE-BINDING-PROTEIN; ACUTE OTITIS-MEDIA; STREPTOCOCCUS-PNEUMONIAE COLONIZATION; INHIBIT COMPLEMENT DEPOSITION; TRIVALENT RECOMBINANT PCPA; HISTIDINE TRIAD PROTEINS; CAPSULAR POLYSACCHARIDE; NASOPHARYNGEAL CARRIAGE; DETOXIFIED PNEUMOLYSIN; FUNCTIONAL ANTIBODIES;

D O I：

10.3389/fcimb.2022.832254

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Streptococcus pneumoniae is an opportunistic pathogen that causes over 1 million deaths annually despite the availability of several multivalent pneumococcal conjugate vaccines (PCVs). Due to the limitations surrounding PCVs along with an evolutionary rise in antibiotic-resistant and unencapsulated strains, conserved immunogenic proteins as vaccine targets continue to be an important field of study for pneumococcal disease prevention. In this review, we provide an overview of multiple classes of conserved surface proteins that have been studied for their contribution to pneumococcal virulence. Furthermore, we discuss the immune responses observed in response to these proteins and their promise as vaccine targets.

引用

页数：14

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