Mechanisms of fetal epigenetics that determine telomere dynamics and health span in adulthood

被引：8

作者：

Ravlic, Sanda ^{[1
]}

Vidacek, Nikolina Skrobot ^{[1
]}

Nanic, Lucia ^{[1
]}

Laganovic, Mario ^{[2
]}

Slade, Neda ^{[3
]}

Jelakovic, Bojan ^{[2
]}

Rubelj, Ivica ^{[1
]}

机构：

[1] RBI, Div Mol Biol, Lab Mol & Cellular Biol, Bijenicka Cesta 54, Zagreb 10000, Croatia

[2] Univ Hosp Ctr Zagreb, Dept Nephrol Hypertens Dialysis & Transplantat, Zagreb, Croatia

[3] RBI, Div Mol Med, Lab Prot Dynam, Zagreb, Croatia

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2018年 / 174卷

关键词：

Epigenetics; Telomere; Fetal development; Cardiovascular disease; Aging; Longevity; INTRAUTERINE GROWTH RESTRICTION; DNA METHYLATION; GLUCOSE-TOLERANCE; HUMAN FIBROBLASTS; MAMMALIAN-CELLS; STEM-CELLS; YOUNG MEN; SUBTELOMERIC METHYLATION; REVERSE-TRANSCRIPTASE; ALZHEIMERS-DISEASE;

D O I：

10.1016/j.mad.2017.08.014

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Advances in epigenetics now enable us to better understand environmental influences on the genetic background of human diseases. This refers especially to fetal development where an adverse intrauterine environment impacts oxygen and nutrient supply to the fetus. Recently, differences in telomere length and telomere loss dynamics among individuals born with intrauterine growth restriction compared to normal controls have been described. In this paper we propose possible molecular mechanisms that (pre)program telomere epigenetics during pregnancy. This programming sets differences in telomere lengths and dynamics of telomere shortening in adulthood and therefore dictates the dynamics of aging and morbidity in later life.

引用

页码：55 / 62

页数：8

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