Derivatization of 1-phenyl substituted 4-amino-2-benzazepin-3-ones:: evaluation of Pd-catalyzed coupling reactions

被引：0

作者：

Ballet, Steven

De Wachter, Rien

Maes, Bert U. W.

Tourwe, Dirk

机构：

[1] Vrije Univ Brussels, Dept Organ Chem, Brussels, Belgium

[2] Univ Antwerp, B-2020 Antwerp, Belgium

来源：

TETRAHEDRON | 2007年 / 63卷 / 18期

关键词：

4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-ones; Pd[0] catalysis; Suzuki reaction; Buchwald-Hartwig reaction; Heck reaction; N-arylation;

D O I：

10.1016/j.tet.2007.02.084

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several Pd-catalyzed reactions were explored to further functionalize the bromo-substitured 4-amino- 1,2,4,5-tetrahydro-2-benzazepin-3-one scaffold (Aba). We report in this paper suitable reaction conditions for Suzuki, Buchwald-Hartwig, and Heck reactions. The substitution pattern of the starting aminobenzazepinone turned out to be crucial for the success of these transition metal-catalyzed reactions, which often required modifications of standard literature procedures. The Pd-catalyzed methods provide access to novel substitution patterns of the Aba scaffold. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：3718 / 3727

页数：10

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