Vincristine and fine motor function of children with acute lymphoblastic leukemia

被引:10
作者
Sabarre, Cheryl L. [1 ]
Rassekh, Shahrad R. [2 ,3 ]
Zwicker, Jill G. [4 ]
机构
[1] British Columbia Childrens Hosp, Bone Marrow Transplant Program, Vancouver, BC V6H 3V4, Canada
[2] British Columbia Childrens Hosp, Vancouver, BC V6H 3V4, Canada
[3] Univ British Columbia, Fac Med, Vancouver, BC V6H 3V4, Canada
[4] Univ British Columbia, Dept Occupat Sci & Occupat Therapy, Vancouver, BC V6H 3V4, Canada
来源
CANADIAN JOURNAL OF OCCUPATIONAL THERAPY-REVUE CANADIENNE D ERGOTHERAPIE | 2014年 / 81卷 / 04期
关键词
Activities of daily living; Movement Assessment Battery for Children-2; Motor skills; Oncology; Pediatrics; MOVEMENT ASSESSMENT BATTERY; THERAPY; PERFORMANCE; SURVIVORS; VALIDITY; DECREASE; CANCER;
D O I
10.1177/0008417414539926
中图分类号
R49 [康复医学];
学科分类号
100215 ;
摘要
Background. Children with acute lymphoblastic leukemia receive vincristine, a chemotherapy drug known to cause peripheral neuropathy. Yet, few studies have examined the association of vincristine to fine motor function. Purpose. This study will describe the fine motor skills and function of children with acute lymphoblastic leukemia on maintenance vincristine. Method. A prospective case series design assessed manual dexterity and parent-reported fine motor dysfunction of 15 children with acute lymphoblastic leukemia in relation to cumulative vincristine exposure. Findings. Almost half of the participants had below-average fine motor skills compared to age-related norms, and 57% of parents observed functional motor problems in their children. No significant associations were found between vincristine, manual dexterity, and functional motor skills. Implications. Early detection and intervention for fine motor difficulties is suggested. Research with a larger sample is necessary to further explore the association of vincristine and fine motor function in this clinical population.
引用
收藏
页码:256 / 264
页数:9
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