Motualevic acids and analogs: Synthesis and antimicrobial structure-activity relationships

被引：5
|
作者：
Cheruku, Pradeep [1 ]
Keffer, Jessica L. [1 ]
Dogo-Isonagie, Cajetan [1 ]
Bewley, Carole A. [1 ]
机构：
[1] NIDDK, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 14期
关键词：
Antibacterial; Gram-positive bacteria; Marine natural product; Dibromo olefin;
D O I：
10.1016/j.bmcl.2010.05.073
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Synthesis of the marine natural products motualevic acids A, E, and analogs in which modi. cations have been made to the omega-brominated lipid (E)-14,14-dibromotetra-deca-2,13-dienoic acid or amino acid unit are reported, together with antimicrobial activities against Staphylococcus aureus, methicillin-resistant S. aureus, Enterococcus faecium, and vancomycin-resistant Enterococcus. Published by Elsevier Ltd.
引用
收藏
页码：4108 / 4111
页数：4
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