Export of O-specific lipopolysaccharide

被引：118

作者：

Valvano, MA

机构：

[1] Univ Western Ontario, Dept Microbiol & Immunol, London, ON N6A 5C1, Canada

[2] Univ Western Ontario, Dept Med, London, ON N6A 5C1, Canada

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2003年 / 8卷

关键词：

O antigen; flippase; translocation; polymerization; ligase; undecaprenol phosphate; ABC transporter; Review;

D O I：

10.2741/1079

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The O antigen is the most surface-exposed component of the lipopolysaccharide (LPS) molecule and its biogenesis involves several complex mechanisms not completely well understood. All of these mechanisms involve biochemical reactions that occur on the cytoplasmic side of the plasma membrane as well as several different translocation pathways that deliver the nascent O antigens in a glycolipid form to the periplasmic side of the plasma membrane. This article discusses our current understanding of the mechanisms operating in the biogenesis of the O-specific LPS.

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页码：S452 / S471

页数：20

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