Emerging roles of non-coding RNAs in scoliosis

被引：29

作者：

Li, Zheng ^{[1
]}

Li, Xingye ^{[2
]}

Shen, Jianxiong ^{[1
]}

Zhang, Lin ^{[3
]}

Chan, Matthew T. V. ^{[3
]}

Wu, William K. K. ^{[3
,4
,5
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthopaed Surg, Beijing, Peoples R China

[2] Tsinghua Univ, Peking Univ, Beijing Jishuitan Hosp, Dept Orthoped Surg,Jishuitan Orthopaed Coll,Clin, Beijing, Peoples R China

[3] Chinese Univ Hong Kong, Dept Anaesthesia & Intens Care, Hong Kong, Peoples R China

[4] Chinese Univ Hong Kong, Inst Digest Dis, Ctr Gut Microbiota Res, State Key Lab Digest Dis, Hong Kong, Peoples R China

[5] Chinese Univ Hong Kong, LKS Inst Hlth Sci, Hong Kong, Peoples R China

来源：

CELL PROLIFERATION | 2020年 / 53卷 / 02期

关键词：

circRNAs; lncRNAs; miRNAs; non-coding RNAs; scoliosis; GENE; PROLIFERATION; PROGRESSION; EXPRESSION; MICRORNA; METHYLATION; PATHWAY; MODELS; CANCER;

D O I：

10.1111/cpr.12736

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Scoliosis, a complex three-dimensional deformity of the spine with the Cobb angle (a measure of the spinal lateral curvature) >10 degree, encompasses a spectrum of pathologies, including congenital, idiopathic, syndromic and neuromuscular aetiologies. The pathogenesis is multifactorial involving both environmental and genetic factors but the exact cellular and molecular mechanisms of disease development remain largely unknown. Emerging evidence showed that non-coding RNAs (ncRNAs), namely microRNAs, long ncRNAs and circular RNAs, are deregulated in many orthopaedic diseases, including scoliosis. Importantly, these deregulated ncRNAs functionally participate in the initiation and progression of scoliosis. Here, we review recent progress in ncRNA research on scoliosis.

引用

页数：7

共 53 条

[1] Circular RNAs: analysis, expression and potential functions [J].

Barrett, Steven P. ;

Salzman, Julia .

DEVELOPMENT, 2016, 143 (11) :1838-1847

[2] The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10 [J].

Bochenek, Gregor ;

Haesler, Robert ;

El Mokhtari, Nour-Eddine ;

Koenig, Inke R. ;

Loos, Bruno G. ;

Jepsen, Soeren ;

Rosenstiel, Philip ;

Schreiber, Stefan ;

Schaefer, Arne S. .

HUMAN MOLECULAR GENETICS, 2013, 22 (22) :4516-4527

[3] LncRNA-SULT1C2A regulates Foxo4 in congenital scoliosis by targeting rno-miR-466c-5p through PI3K-ATK signalling [J].

Chen, Chong ;

Tan, Haining ;

Bi, Jiaqi ;

Li, Lin ;

Rong, Tianhua ;

Lin, Youxi ;

Sun, Peiyu ;

Liang, Jinqian ;

Jiao, Yang ;

Li, Zheng ;

Sun, Liang ;

Shen, Jianxiong .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2019, 23 (07) :4582-4591

[4] Identification of Competing Endogenous RNA Regulatory Networks in Vitamin A Deficiency-Induced Congenital Scoliosis by Transcriptome Sequencing Analysis [J].

Chen, Chong ;

Tan, Haining ;

Bi, Jiaqi ;

Li, Zheng ;

Rong, Tianhua ;

Lin, Youxi ;

Sun, Liang ;

Li, Xingye ;

Shen, Jianxiong .

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018, 48 (05) :2134-2146

[5]

Chen WK, 2017, Cell Prolif, V50, P1, DOI DOI 10.1111/CPR.2017.50.ISSUE-110.1111/CPR.12313

[6]

Enjie X, 2019, BIOMED RES INT, V4678969, P1

[7] An analysis of PAX1 in the development of vertebral malformations [J].

Giampietro, PF ;

Raggio, CL ;

Reynolds, CE ;

Shukla, SK ;

McPherson, E ;

Ghebranious, N ;

Jacobsen, FS ;

Kumar, V ;

Faciszewski, T ;

Pauli, RM ;

Rasmussen, K ;

Burmester, JK ;

Zaleski, C ;

Merchant, S ;

David, D ;

Weber, JL ;

Glurich, I ;

Blank, RD .

CLINICAL GENETICS, 2005, 68 (05) :448-453

[8] Genetic Aspects of Congenital and Idiopathic Scoliosis [J].

Giampietro, Philip F. .

SCIENTIFICA, 2012, 2012

[9] Candidate gene analysis and exome sequencing confirm LBX1 as a susceptibility gene for idiopathic scoliosis [J].

Grauers, Anna ;

Wang, Jingwen ;

Einarsdottir, Elisabet ;

Simony, Ane ;

Danielsson, Aina ;

Akesson, Kristina ;

Ohlin, Acke ;

Halldin, Klas ;

Grabowski, Pawel ;

Tenne, Max ;

Laivuori, Hannele ;

Dahlman, Ingrid ;

Andersen, Mikkel ;

Christensen, Steen Bach ;

Karlsson, Magnus K. ;

Jiao, Hong ;

Kere, Juha ;

Gerdhem, Paul .

SPINE JOURNAL, 2015, 15 (10) :2239-2246

[10] ptk7 mutant zebrafish models of congenital and idiopathic scoliosis implicate dysregulated Wnt signalling in disease [J].

Hayes, Madeline ;

Gao, Xiaochong ;

Yu, Lisa X. ;

Paria, Nandina ;

Henkelman, R. Mark ;

Wise, Carol A. ;

Ciruna, Brian .

NATURE COMMUNICATIONS, 2014, 5

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