Redox-responsive nanoparticles self-assembled from porphyrin-betulinic acid conjugates for chemo- and photodynamic therapy

被引：7
作者：
Ozdemir, Zulal [1 ,2 ]
Yang, Mengyao [3 ]
Kim, Gyoungmi [3 ]
Bildziukevich, Uladzimir [1 ,2 ]
Saman, David [4 ]
Li, Xingshu [5 ]
Yoon, Juyoung [3 ]
Wimmer, Zdenek [1 ,2 ]
机构：
[1] Univ Chem & Technol, Dept Chem Nat Cpds, Tech 5, Prague 16628 6, Czech Republic
[2] Czech Acad Sci, Isotope Lab, Inst Expt Bot, Videnska 1083, Prague 14220 4, Czech Republic
[3] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea
[4] Czech Acad Sci, Dept NMR Spect, Inst Organ Chem & Biochem, Flemingovo Namesti 2, Prague 16610 6, Czech Republic
[5] Fuzhou Univ, Coll Chem, Fuzhou 350108, Peoples R China
来源：
DYES AND PIGMENTS | 2021年 / 190卷
基金：
新加坡国家研究基金会; 中国国家自然科学基金;
关键词：
ROS; Photodynamic therapy; Redox-responsive; Tumour targeting; Self-assembled nanoparticles; CANCER; AMIDES; DERIVATIVES; PHOTOSENSITIZERS; CYTOTOXICITY; NANOCARRIERS;
D O I：
10.1016/j.dyepig.2021.109307
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The redox-responsive nanoparticle (NanoP-ss-BA) is designed by linking the porphyrin derivative (P) to the naturally occurring betulinic acid (BA) through a disulphide bond. A GSH triggered disassembly of NanoP-ss-BA effectively promotes a singlet oxygen (1O2) production, but also releases lipophilic anticancer drug, BA in situ. Beside this, high phototoxicity of NanoP-ss-BA serves it as a good candidate for photodynamic therapy (PDT).
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页数：10
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