Direct roles of SPEECHLESS in the specification of stomatal self-renewing cells

被引：173

作者：

Lau, On Sun ^{[1
]}

Davies, Kelli A. ^{[1
]}

Chang, Jessica ^{[1
]}

Adrian, Jessika ^{[1
]}

Rowe, Matthew H. ^{[1
]}

Ballenger, Catherine E. ^{[2
]}

Bergmann, Dominique C. ^{[1
,2
,3
]}

机构：

[1] Stanford Univ, Dept Biol, Stanford, CA 94305 USA

[2] Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA

[3] Carnegie Inst Sci, Stanford, CA 94305 USA

来源：

SCIENCE | 2014年 / 345卷 / 6204期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

GENE-EXPRESSION; ARABIDOPSIS; DIVISION; DIFFERENTIATION; GROWTH; BRASSINOSTEROIDS; ELONGATION; POLARITY; LINEAGE; PLANT;

D O I：

10.1126/science.1256888

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Lineage-specific stem cells are critical for the production and maintenance of specific cell types and tissues in multicellular organisms. In Arabidopsis, the initiation and proliferation of stomatal lineage cells is controlled by the basic helix-loop-helix transcription factor SPEECHLESS (SPCH). SPCH-driven asymmetric and self-renewing divisions allow flexibility in stomatal production and overall organ growth. How SPCH directs stomatal lineage cell behaviors, however, is unclear. Here, we improved the chromatin immunoprecipitation (ChIP) assay and profiled the genome-wide targets of Arabidopsis SPCH in vivo. We found that SPCH controls key regulators of cell fate and asymmetric cell divisions and modulates responsiveness to peptide and phytohormone-mediated intercellular communication. Our results delineate the molecular pathways that regulate an essential adult stem cell lineage in plants.

引用

页码：1605 / 1609

页数：5

共 29 条

[11] Brassinosteroid regulates stomatal development by GSK3-mediated inhibition of a MAPK pathway [J].