Gut-Brain Axis and Mood Disorder

被引：82

作者：

Liu, Lu ^{[1
]}

Zhu, Gang ^{[1
]}

机构：

[1] China Med Univ, Dept Psychiat, Affiliated Hosp 1, Shenyang, Liaoning, Peoples R China

来源：

FRONTIERS IN PSYCHIATRY | 2018年 / 9卷

基金：

中国国家自然科学基金;

关键词：

intestinal microbiota; gut-brain axis; neuro-endocrine-immune; mood disorders; stress; MICROBIOME COMPOSITION; BIPOLAR DISORDER; BEHAVIOR; STRESS; DEPRESSION; PSYCHOBIOTICS; LACTOBACILLUS; PROBIOTICS; ANXIETY; RATS;

D O I：

10.3389/fpsyt.2018.00223

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Humans have over 100 trillion bacteria, highly abundant in the intestinal tract. Evidence suggests that intestinal microbiota is associated with the neuro-endocrine-immune pathways and can be associated with various mood disorders. This review summarizes findings from studies looking into neurobiochemical, neuroendocrine, and neuroimmune systemmechanisms of the gut-brain axis to determine the relationship between intestinal microbiota and mood disorders. The effect of prebiotics, probiotics and antibiotics on mood disorders are also discussed, with the aim to propose some new therapeutic strategies for mood disorders.

引用

页数：8

共 41 条

[1] Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder [J].

Aizawa, Emiko ;

Tsuji, Hirokazu ;

Asahara, Takashi ;

Takahashi, Takuya ;

Teraishi, Toshiya ;

Yoshida, Sumiko ;

Ota, Miho ;

Koga, Norie ;

Hattori, Kotaro ;

Kunugi, Hiroshi .

JOURNAL OF AFFECTIVE DISORDERS, 2016, 202 :254-257

[2]

Allen AP, 2017, SOC PERSONAL PSYCHOL, V11, DOI 10.1111/spc3.12309

[3] Lost in Translation: The Gut Microbiota in Psychiatric Illness [J].

Anglin, Rebecca ;

Surette, Michael ;

Moayyedi, Paul ;

Bercik, Premysl .

CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2015, 60 (10) :460-463

[4] Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: part III - convergence toward clinical trials [J].

Bested, Alison C. ;

Logan, Alan C. ;

Selhub, Eva M. .

GUT PATHOGENS, 2013, 5

[5] Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: Part II - contemporary contextual research [J].

Bested, Alison C. ;

Logan, Alan C. ;

Selhub, Eva M. .

GUT PATHOGENS, 2013, 5

[6] Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve [J].

Bravo, Javier A. ;

Forsythe, Paul ;

Chew, Marianne V. ;

Escaravage, Emily ;

Savignac, Helene M. ;

Dinan, Timothy G. ;

Bienenstock, John ;

Cryan, John F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (38) :16050-16055

[7] Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects and Reverse the Impact of Chronic Stress in Mice [J].

Burokas, Aurelijus ;

Arboleya, Silvia ;

Moloney, Rachel D. ;

Peterson, Veronica L. ;

Murphy, Kiera ;

Clarke, Gerard ;

Stanton, Catherine ;

Dinan, Timothy G. ;

Cryan, John F. .

BIOLOGICAL PSYCHIATRY, 2017, 82 (07) :472-487

[8] Microbiome-Gut-Brain Axis: Probiotics and Their Association With Depression [J].

Cepeda, M. Soledad ;

Katz, Eva G. ;

Blacketer, Clair .

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES, 2017, 29 (01) :39-44

[9] The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner [J].

Clarke, G. ;

Grenham, S. ;

Scully, P. ;

Fitzgerald, P. ;

Moloney, R. D. ;

Shanahan, F. ;

Dinan, T. G. ;

Cryan, J. F. .

MOLECULAR PSYCHIATRY, 2013, 18 (06) :666-673

[10] Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats [J].

Crumeyrolle-Arias, Michele ;

Jaglin, Mathilde ;

Bruneau, Aurelia ;

Vancassel, Sylvie ;

Cardona, Ana ;

Dauge, Valerie ;

Naudon, Laurent ;

Rabot, Sylvie .

PSYCHONEUROENDOCRINOLOGY, 2014, 42 :207-217

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