Leptin and the regulation of body weight

被引：165

作者：

Considine, RV ^{[1
]}

Caro, JF ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Jefferson Med Coll, Dept Med, Div Endocrinol & Metab, Philadelphia, PA 19107 USA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 1997年 / 29卷 / 11期

关键词：

ob gene; leptin; leptin receptor; obesity;

D O I：

10.1016/S1357-2725(97)00050-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Leptin has received considerable attention as a newly recognized metabolic hormone and for its potential for therapeutic use in the treatment of human obesity. Furthermore, defects in the leptin signal pathway that result in obesity in animal models have raised the possibility of a similar etiology for obesity in humans. This review will summarize the current findings on leptin in both humans and rodents. These findings mill be discussed with respect to our view of the physiology and potential for pathophysiology in leptin-mediated regulation of body weight and composition. (C) 1997 Published by Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：1255 / 1272

页数：18

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