Measuring the thermodynamics of RNA secondary structure formation

被引：0
作者：
SantaLucia, J
Turner, DH [1 ]
机构：
[1] Univ Rochester, Dept Chem, Rochester, NY 14627 USA
[2] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA
来源：
BIOPOLYMERS | 1997年 / 44卷 / 03期
关键词：
RNA; secondary structure; thermodynamics; optical melting; measurement errors;
D O I：
10.1002/(SICI)1097-0282(1997)44:3<309::AID-BIP8>3.3.CO;2-Y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The thermodynamics of RNA secondary structure formation in small model systems provides a database Sol-predicting RNA structure from sequence. Methods Sor making these measurements are reviewed with emphasis on optical methods and treatment of experimental errors. Analysis of experimental results in terms of simple nearest-neighbor models is presented. Some measured sequence dependences of non-Watson-Crick motifs are discussed. (C) 1998 John Wiley & Sons, Inc.
引用
收藏
页码：309 / 319
页数：11
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