Analysis of health-related biomarkers between vegetarians and non-vegetarians: A multi-biomarker approach

被引：18

作者：

Gajski, Goran ^{[1
]}

Geric, Marko ^{[1
]}

Lovrencic, Marijana Vucic ^{[2
]}

Bozicevic, Sandra ^{[2
]}

Rubelj, Ivica ^{[3
]}

Nanic, Lucia ^{[3
]}

Vidacek, Nikolina Skrobot ^{[3
]}

Bendix, Laila ^{[4
]}

Peraica, Maja ^{[5
]}

Rasic, Dubravka ^{[5
]}

Domijan, Ana-Marija ^{[6
]}

Gluscic, Valentina ^{[5
]}

Jurasovic, Jasna ^{[7
]}

Orct, Tatjana ^{[7
]}

Avdagic, Selma Cvijetic ^{[8
]}

Jurak, Gordana ^{[9
]}

Bosnir, Jasna ^{[9
]}

Garaj-Vrhovac, Vera ^{[1
]}

机构：

[1] Inst Med Res & Occupat Hlth, Mutagenesis Unit, Ksaverska Cesta 2,POB 291, Zagreb 10000, Croatia

[2] Merkur Univ Hosp, Dept Lab Med, Zagreb, Croatia

[3] Rudjer Boskovic Inst, Div Mol Biol, Lab Mol & Cellular Biol, Zagreb, Croatia

[4] Univ Southern Denmark, Danish Aging Res Ctr, Odense, Denmark

[5] Inst Med Res & Occupat Hlth, Toxicol Unit, Zagreb, Croatia

[6] Univ Zagreb, Fac Pharm & Biochem, Dept Pharmaceut Bot, Zagreb, Croatia

[7] Inst Med Res & Occupat Hlth, Analyt Toxicol & Mineral Metab Unit, Zagreb, Croatia

[8] Inst Med Res & Occupat Hlth, Occupat Hlth & Environm Med, Zagreb, Croatia

[9] Andrija Stampar Teaching Inst Publ Hlth, Dept Environm Protect & Hlth Ecol, Zagreb, Croatia

来源：

JOURNAL OF FUNCTIONAL FOODS | 2018年 / 48卷

关键词：

Vegetarians; Non-vegetarians; Dietary habits; Oxidative stress; Genomic instability; Health-related biomarkers; BLOCK MICRONUCLEUS ASSAY; BONE-MINERAL DENSITY; LIFE-STYLE CHANGES; DNA-DAMAGE; HOMOCYSTEINE STATUS; ANTIOXIDANT SUPPLEMENTATION; MICRONUTRIENT DEFICIENCIES; CHROMOSOMAL INSTABILITY; CARDIOVASCULAR-DISEASE; TELOMERASE ACTIVITY;

D O I：

10.1016/j.jff.2018.07.054

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

This study was performed in a group of adult vegetarians (N = 40) and matched non-vegetarian subjects (N = 40) in order to analyse differences in health-related biomarkers. Obtained results revealed differences in various biomarkers between subjects on a traditional mixed and vegetarian diet, indicating that vegetarians have a lower nutritional status of some nutrients (Ca, Cu and Zn, and vitamins B-12 and D) accompanied with a lower antioxidant defence system (glutathione) and higher homocysteine and genome damage (micronuclei and DNA strand breaks), along with shorter telomeres. This suggests that the supplementation of animal derived nutrients to this particular dietary group would be beneficial for the improvement of some measured health-related biomarkers. However, the level of certain toxic metals (As and Hg) was higher in non-vegetarians. The presented multi-biomarker approach implies the necessity of evaluating a large number of different health-related biomarkers in order to obtain clear insight into dietary preferences and health outcomes.

引用

页码：643 / 653

页数：11

共 91 条

[1] DNA damage from micronutrient deficiencies is likely to be a major cause of cancer [J].

Ames, BN .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2001, 475 (1-2) :7-20

[2] Micronutrient deficiencies - A major cause of DNA damage [J].

Ames, BN .

CANCER PREVENTION: NOVEL NUTRIENT AND PHARMACEUTICAL DEVELOPMENTS, 1999, 889 :87-106

[3] Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies [J].

Barba, C ;

Cavalli-Sforza, T ;

Cutter, J ;

Darnton-Hill, I ;

Deurenberg, P ;

Deurenberg-Yap, M ;

Gill, T ;

James, P ;

Ko, G ;

Miu, AH ;

Kosulwat, V ;

Kumanyika, S ;

Kurpad, A ;

Mascie-Taylor, N ;

Moon, HK ;

Nishida, C ;

Noor, MI ;

Reddy, KS ;

Rush, E ;

Schultz, JT ;

Seidell, J ;

Stevens, J ;

Swinburn, B ;

Tan, K ;

Weisell, R ;

Wu, ZS ;

Yajnik, CS ;

Yoshiike, N ;

Zimmet, P .

LANCET, 2004, 363 (9403) :157-163

[4] Folic acid deficiency increases chromosomal instability, chromosome 21 aneuploidy and sensitivity to radiation-induced micronuclei [J].

Beetstra, S ;

Thomas, P ;

Salisbury, C ;

Turner, J ;

Fenech, M .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2005, 578 (1-2) :317-326

[5] FAST DETERMINATION OF OCHRATOXIN-A IN SERUM BY LIQUID-CHROMATOGRAPHY - COMPARISON WITH ENZYMATIC SPECTROFLUORIMETRIC METHOD [J].

BEKER, D ;

RADIC, B .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1991, 570 (02) :441-445

[6] Wine consumption and intestinal redox homeostasis [J].

Biasi, Fiorella ;

Deiana, Monica ;

Guina, Tina ;

Gamba, Paola ;

Leonarduzzi, Gabriella ;

Poli, Giuseppe .

REDOX BIOLOGY, 2014, 2 :795-802

[7] The role of low acid load in vegetarian diet on bone health: a narrative review [J].

Burckhardt, Peter .

SWISS MEDICAL WEEKLY, 2016, 146 :w14277

[8] Nutrition and Health - The Association between Eating Behavior and Various Health Parameters: A Matched Sample Study [J].

Burkert, Nathalie T. ;

Muckenhuber, Johanna ;

Grossschaedl, Franziska ;

Rasky, Eva ;

Freidl, Wolfgang .

PLOS ONE, 2014, 9 (02)

[9] Total cardiovascular risk profile of Taiwanese vegetarians [J].

Chen, C-W ;

Lin, Y-L ;

Lin, T-K ;

Lin, C-T ;

Chen, B-C ;

Lin, C-L .

EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2008, 62 (01) :138-144

[10] Nutrition Concerns and Health Effects of Vegetarian Diets [J].

Craig, Winston John .

NUTRITION IN CLINICAL PRACTICE, 2010, 25 (06) :613-620

← 1 2 3 4 5 6 7 8 9 10 →