Emerging Therapies in Hereditary Angioedema

被引：30

作者：

Chen, Meng ^{[1
]}

Riedl, Marc A. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Med Allergy & Immunol, Div Rheumatol, 8899 Univ City Lane,Suite 230, San Diego, CA 92122 USA

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2017年 / 37卷 / 03期

关键词：

Angioedema; Emerging therapies; C1 esterase inhibitor; Bradykinin; Kallikrein; Factor XII; PLASMA KALLIKREIN; C1; INHIBITOR; OMALIZUMAB; HAE;

D O I：

10.1016/j.iac.2017.03.003

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Remarkable progress has been made in the treatment of bradykinin-mediated angioedema with the advent of multiple new therapies. Patients now have effective medications available for prophylaxis and treatment of acute attacks. However, hereditary angioedema is a burdensome disease that can lead to debilitating and dangerous angioedema episodes associated with significant costs for individuals and society. The burden of treatment must be addressed regarding medication administration difficulties, treatment complications, and adverse side effects. New therapies are being investigated and may offer solutions to these challenges. This article reviews the emerging therapeutic options for the treatment of HAE.

引用

页码：585 / +

页数：12

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