Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

被引:33
作者
Ali, Eunus S. [1 ]
Akter, Shamima [2 ]
Ramproshad, Sarker [3 ]
Mondal, Banani [3 ]
Riaz, Thoufiqul Alam [4 ,5 ]
Islam, Muhammad Torequl [6 ]
Khan, Ishaq N. [7 ]
Docea, Anca Oana [8 ]
Calina, Daniela [9 ]
Sharifi-Rad, Javad [10 ]
Cho, William C. [11 ]
机构
[1] Flinders Univ S Australia, Coll Med & Publ Hlth, Bedford Pk, SA 5042, Australia
[2] George Mason Univ, Dept Bioinformat & Computat Biol, Fairfax, VA 22030 USA
[3] Ranada Prasad Shaha Univ, Dept Pharm, Narayanganj 1400, Bangladesh
[4] Jeonbuk Natl Univ, Med Sch, Dept Pharmacol, Jeonju 54907, South Korea
[5] Jeonbuk Natl Univ, Med Sch, Inst New Drug Dev, Jeonju 54907, South Korea
[6] Bangabandhu Sheikh Mujibur Rahman Sci & Technol U, Life Sci Fac, Dept Pharm, Gopalganj 8100, Bangladesh
[7] Khyber Med Univ, Inst Basic Med Sci, Peshawar 25100, Pakistan
[8] Univ Med & Pharm Craiova, Dept Toxicol, Craiova 200349, Romania
[9] Univ Med & Pharm Craiova, Dept Clin Pharm, Craiova 200349, Romania
[10] Univ Azuay, Fac Med, Cuenca, Ecuador
[11] Queen Elizabeth Hosp, Dept Clin Oncol, Hong Kong, Peoples R China
基金
英国科研创新办公室;
关键词
Cancer; MAPK (ERK); Ras signaling; Ras oncogenes; Molecular mechanisms; Natural bioactive compounds; Chemoresistance; Chemoprevention; HEPATOCELLULAR-CARCINOMA; CHORIOCARCINOMA CELLS; SIGNALING PATHWAYS; KAPPA-B; MAPK; APOPTOSIS; PROLIFERATION; PI3K/AKT; SULFORAPHANE; SUPPRESSION;
D O I
10.1186/s12935-022-02666-z
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
MAPK (mitogen-activated protein kinase) or ERK (extracellular-signal-regulated kinase) pathway is an important link in the transition from extracellular signals to intracellular responses. Because of genetic and epigenetic changes, signaling cascades are altered in a variety of diseases, including cancer. Extant studies on the homeostatic and pathologic behavior of MAPK signaling have been conducted; however, much remains to be explored in preclinical and clinical research in terms of regulation and action models. MAPK has implications for cancer therapy response, more specifically in response to experimental MAPK suppression, compensatory mechanisms are activated. The current study investigates MAPK as a very complex cell signaling pathway that plays roles in cancer treatment response, cellular normal conduit maintenance, and compensatory pathway activation. Most MAPK inhibitors, unfortunately, cause resistance by activating compensatory feedback loops in tumor cells and tumor microenvironment components. As a result, innovative combinatorial treatments for cancer management must be applied to limit the likelihood of alternate pathway initiation as a possibility for generating novel therapeutics based on incorporation in translational research. We summarize current knowledge about the implications of ERK (MAPK) in cancer, as well as bioactive products from plants, microbial organisms or marine organisms, as well as the correlation with their chemical structures, which modulate this pathway for the treatment of different types of cancer.
引用
收藏
页数:15
相关论文
共 131 条
[11]   Nutrigenomics in cancer: Revisiting the effects of natural compounds [J].
Braicu, Cornelia ;
Mehterov, Nikolay ;
Vladimirov, Boyan ;
Sarafian, Victoria ;
Nabavi, Seyed Mohammad ;
Atanasov, Atanas G. ;
Berindan-Neagoe, Ioana .
SEMINARS IN CANCER BIOLOGY, 2017, 46 :84-106
[12]   NCRNA Combined Therapy as Future Treatment Option for Cancer [J].
Braicu, Cornelia ;
Catana, Cristina ;
Calin, George A. ;
Berindan-Neagoe, Ioana .
CURRENT PHARMACEUTICAL DESIGN, 2014, 20 (42) :6565-6574
[13]   p53siRNA therapy reduces cell proliferation, migration and induces apoptosis in triple negative breast cancer cells [J].
Braicu, Cornelia ;
Pileczki, Valentina ;
Irimie, Alexandru ;
Berindan-Neagoe, Ioana .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2013, 381 (1-2) :61-68
[14]   Inhibitory Effect of CAPE and Kaempferol in Colon Cancer Cell LinesPossible Implications in New Therapeutic Strategies [J].
Budisan, Liviuta ;
Gulei, Diana ;
Jurj, Ancuta ;
Braicu, Cornelia ;
Zanoaga, Oana ;
Cojocneanu, Roxana ;
Pop, Laura ;
Raduly, Lajos ;
Barbat, Alexandru ;
Moldovan, Alin ;
Moldovan, Cristian ;
Tigu, Adrian Bogdan ;
Ionescu, Calin ;
Atanasov, Atanas G. ;
Irimie, Alexandru ;
Berindan-Neagoe, Ioana .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (05)
[15]   Dietary Intervention by Phytochemicals and Their Role in Modulating Coding and Non-Coding Genes in Cancer [J].
Budisan, Liviuta ;
Gulei, Diana ;
Zanoaga, Oana Mihaela ;
Irimie, Alexandra Iulia ;
Chira, Sergiu ;
Braicu, Cornelia ;
Gherman, Claudia Diana ;
Berindan-Neagoe, Ioana .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (06)
[16]   Molecular and cellular stratagem of brain metastases associated with melanoma [J].
Buga, Ana-Maria ;
Docea, Anca Oana ;
Albu, Carmen ;
Malin, Ramona Denise ;
Branisteanu, Daciana Elena ;
Ianosi, Gabriel ;
Ianosi, Simona Laura ;
Iordache, Andrei ;
Calina, Daniela .
ONCOLOGY LETTERS, 2019, 17 (05) :4170-4175
[17]  
Cainap C, 2016, J BUON, V21, P349
[18]   The Treatment of Cognitive, Behavioural and Motor Impairments from Brain Injury and Neurodegenerative Diseases through Cannabinoid System Modulation-Evidence from In Vivo Studies [J].
Calina, Daniela ;
Buga, Ana Maria ;
Mitroi, Mihaela ;
Buha, Aleksandra ;
Caruntu, Constantin ;
Scheau, Cristian ;
Bouyahya, Abdelhakim ;
El Omari, Nasreddine ;
El Menyiy, Naoual ;
Docea, Anca Oana .
JOURNAL OF CLINICAL MEDICINE, 2020, 9 (08) :1-28
[19]   Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases [J].
Cargnello, Marie ;
Roux, Philippe P. .
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2011, 75 (01) :50-83
[20]   Genistein inhibits the growth and regulates the migration and invasion abilities of melanoma cells via the FAK/paxillin and MAPK pathways [J].
Cui, Shuna ;
Wang, Juan ;
Wu, Qingqing ;
Qian, Jing ;
Yang, Changshui ;
Bo, Ping .
ONCOTARGET, 2017, 8 (13) :21674-21691