A digital microfluidic biosensor for multianalyte detection

被引：0

作者：

Srinivasan, V ^{[1
]}

Pamula, V ^{[1
]}

Pollack, M ^{[1
]}

Fair, R ^{[1
]}

机构：

[1] Duke Univ, Dept Elect Engn, Durham, NC 27708 USA

来源：

MEMS-03: IEEE THE SIXTEENTH ANNUAL INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS | 2003年

关键词：

D O I：

暂无

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

A microfluidic lab-on-chip (LoC) for measuring the concentration of human body metabolites, using submicroliter droplets as reaction chambers, is presented in this paper. The device is based on the manipulation of droplets using the principle of electrowetting and is integrated with an optical absorbance measurement system for detection. We have demonstrated the detection of glucose using a colorimetric enzyme-kinetic assay in less than 40 seconds. The sensor response is linear in the range of 25mg/dl to 300mg/dl, with less than 5% deviation from linearity at the upper limit. In addition to glucose, we have also demonstrated the feasibility of lactate, glutamate, and pyruvate assays using our system.

引用

页码：327 / 330

页数：4

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