The Current Role of Platelet Function Testing in Clinical Practice

被引：9

作者：

Mason, George A. ^{[1
]}

Rabbolini, David J. ^{[2
,3
,4
]}

机构：

[1] Royal North Shore Hosp, Dept Haematol & Transfus Med, Sydney, NSW, Australia

[2] Lismore Base Hosp, Lismore Canc & Haematol Unit, 70-72 Hunter St, Lismore, NSW 2480, Australia

[3] Univ Sydney, Northern Clin Sch, Sydney, NSW, Australia

[4] Univ Sydney, Rural Clin Sch, Sydney, NSW, Australia

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2021年 / 47卷 / 07期

关键词：

platelet function testing; light transmission aggregometry; platelet reactivity; inherited platelet function disorder; PERCUTANEOUS CORONARY INTERVENTION; MULTIPLE ELECTRODE AGGREGOMETRY; CLOPIDOGREL-TREATED PATIENTS; STORAGE POOL DEFICIENCY; LIGHT TRANSMISSION; WHOLE-BLOOD; ANTIPLATELET THERAPY; DIAGNOSIS; AGGREGATION; REACTIVITY;

D O I：

10.1055/s-0041-1728786

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Platelet dysfunction, whether hereditary or acquired, may increase an individual's risk of spontaneous, posttraumatic, or postoperative bleeding. Conversely, increased platelet reactivity on antiplatelet agents following vascular (in particular, coronary vascular) intervention may increase the risk of thrombosis and adverse vascular events. The aim of platelet function testing is to identify and characterize platelet dysfunction in these settings to inform bleeding/ thrombosis risk and guide perioperative prophylactic management strategies. A vast array of screening and diagnostic tests is available for this purpose. The successful clinical application of platelet function tests depends on the knowledge of their analytical strengths and limitations and the correct extrapolation of derived results to a particular clinical scenario. This review critically appraises traditional and contemporary platelet function testing focusing on their role in clinical practice.

引用

页码：843 / 854

页数：12

共 79 条

[11] 96-well plate-based aggregometry [J].

Chan, Melissa V. ;

Armstrong, Paul C. ;

Warner, Timothy D. .

PLATELETS, 2018, 29 (07) :650-655

[12] Not all light transmission aggregation assays are created equal: qualitative differences between light transmission and 96-well plate aggregometry [J].

Chan, Melissa V. ;

Leadbeater, Philip D. ;

Watson, Steve P. ;

Warner, Timothy D. .

PLATELETS, 2018, 29 (07) :686-689

[13] Standardised optical multichannel (optimul) platelet aggregometry using high-speed shaking and fixed time point readings [J].

Chan, Melissa V. ;

Warner, Timothy D. .

PLATELETS, 2012, 23 (05) :404-408

[14] Optical multichannel (optimul) platelet aggregometry in 96-well plates as an additional method of platelet reactivity testing [J].

Chan, Melissa V. ;

Armstrong, Paul C. J. ;

Papalia, Francesco ;

Kirkby, Nicholas S. ;

Warner, Timothy D. .

PLATELETS, 2011, 22 (07) :485-494

[15] Bedside Monitoring to Adjust Antiplatelet Therapy for Coronary Stenting [J].

Collet, Jean-Philippe ;

Cuisset, Thomas ;

Range, Gregoire ;

Cayla, Guillaume ;

Elhadad, Simon ;

Pouillot, Christophe ;

Henry, Patrick ;

Motreff, Pascal ;

Carrie, Didier ;

Boueri, Ziad ;

Belle, Loic ;

Van Belle, Eric ;

Rousseau, Helene ;

Aubry, Pierre ;

Monsegu, Jacques ;

Sabouret, Pierre ;

O'Connor, Stephen A. ;

Abtan, Jeremie ;

Kerneis, Mathieu ;

Saint-Etienne, Christophe ;

Barthelemy, Olivier ;

Beygui, Farzin ;

Silvain, Johanne ;

Vicaut, Eric ;

Montalescot, Gilles .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (22) :2100-2109

[16] Assessment of three point-of-care platelet function assays in adult trauma patients [J].

Connelly, Christopher Robert ;

Yonge, John D. ;

McCully, Sean P. ;

Hart, Kyle D. ;

Hilliard, Thomas C. ;

Lape, Diane E. ;

Watson, Justin J. ;

Rick, Beth ;

Houser, Ben ;

Deloughery, Thomas G. ;

Schreiber, Martin A. ;

Kiraly, Laszlo N. .

JOURNAL OF SURGICAL RESEARCH, 2017, 212 :260-269

[17] Evaluation of participants with suspected heritable platelet function disorders including recommendation and validation of a streamlined agonist panel [J].

Dawood, Ban B. ;

Lowe, Gillian C. ;

Lordkipanidze, Marie ;

Bem, Danai ;

Daly, Martina E. ;

Makris, Mike ;

Mumford, Andrew ;

Wilde, Jonathan T. ;

Watson, Steve P. .

BLOOD, 2012, 120 (25) :5041-5049

[18] Identification of platelet function defects by multi-parameter assessment of thrombus formation [J].

de Witt, Susanne M. ;

Swieringa, Frauke ;

Cavill, Rachel ;

Lamers, Moniek M. E. ;

van Kruchten, Roger ;

Mastenbroek, Tom ;

Baaten, Constance ;

Coort, Susan ;

Pugh, Nicholas ;

Schulz, Ansgar ;

Scharrer, Inge ;

Jurk, Kerstin ;

Zieger, Barbara ;

Clemetson, Kenneth J. ;

Farndale, Richard W. ;

Heemskerk, Johan W. M. ;

Cosemans, Judith M. E. M. .

NATURE COMMUNICATIONS, 2014, 5

[19] Evaluation of a whole blood remote platelet function test for the diagnosis of mild bleeding disorders [J].

Dovlatova, N. ;

Lordkipanidze, M. ;

Lowe, G. C. ;

Dawood, B. ;

May, J. ;

Heptinstall, S. ;

Watson, S. P. ;

Fox, S. C. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2014, 12 (05) :660-665

[20] Current status and future prospects for platelet function testing in the diagnosis of inherited bleeding disorders [J].

Dovlatova, Natalia .

BRITISH JOURNAL OF HAEMATOLOGY, 2015, 170 (02) :150-161

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