Exposure of the developing brain to a wide variety of drugs of abuse (e.g., stimulants, opioids, ethanol, etc.) can induce life-long changes in behavior and neural circuitry. However, the long-term effects of exposure to therapeutic, psychotropic drugs have only recently begun to be appreciated. Antipsychotic drugs are little studied in this regard. Here, we quantitatively analyzed dendritic architecture in adult mice treated with paradigmatic typical- (haloperidol) or atypical (olanzapine) antipsychotic drugs at developmental stages corresponding to fetal or fetal plus early childhood stages in humans. In layer 3 pyramidal cells of the medial and orbital prefrontal cortices and the parietal cortex and in spiny neurons of the core of the nucleus accumbens, both drugs induced significant changes (predominantly reductions) in the amount and complexity of dendritic arbor and the density of dendritic spines. The drug-induced plasticity of dendritic architecture suggests changes in patterns of neuronal connectivity in multiple brain regions that are likely to be functionally significant. Synapse 64:191-199, 2010. (C) 2009 Wiley-Liss, Inc.
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Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USACornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA
Li, CJ
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Brake, WG
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机构:Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA
Brake, WG
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Romeo, RD
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机构:Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA
Romeo, RD
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Dunlop, JC
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机构:Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA
Dunlop, JC
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Gordon, M
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机构:Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA
Gordon, M
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Buzescu, R
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机构:Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA
Buzescu, R
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Magarinos, AM
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机构:Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA
Magarinos, AM
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Allen, PB
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机构:Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA
Allen, PB
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Greengard, P
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Luine, V
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机构:Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA
Luine, V
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McEwen, BS
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机构:Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA
机构:
Rockefeller Univ, Harold & Margaret Milliken Hatch Lab Neuroendocri, New York, NY 10021 USARockefeller Univ, Harold & Margaret Milliken Hatch Lab Neuroendocri, New York, NY 10021 USA
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Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USACornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA
Li, CJ
;
Brake, WG
论文数: 0引用数: 0
h-index: 0
机构:Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA
Brake, WG
;
Romeo, RD
论文数: 0引用数: 0
h-index: 0
机构:Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA
Romeo, RD
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Dunlop, JC
论文数: 0引用数: 0
h-index: 0
机构:Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA
Dunlop, JC
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Gordon, M
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h-index: 0
机构:Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA
Gordon, M
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Buzescu, R
论文数: 0引用数: 0
h-index: 0
机构:Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA
Buzescu, R
;
Magarinos, AM
论文数: 0引用数: 0
h-index: 0
机构:Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA
Magarinos, AM
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Allen, PB
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h-index: 0
机构:Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA
Allen, PB
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机构:
Greengard, P
;
Luine, V
论文数: 0引用数: 0
h-index: 0
机构:Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA
Luine, V
;
McEwen, BS
论文数: 0引用数: 0
h-index: 0
机构:Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA
机构:
Rockefeller Univ, Harold & Margaret Milliken Hatch Lab Neuroendocri, New York, NY 10021 USARockefeller Univ, Harold & Margaret Milliken Hatch Lab Neuroendocri, New York, NY 10021 USA