Early Exposure to Haloperidol or Olanzapine Induces Long-Term Alterations of Dendritic Form

被引:38
作者
Frost, Douglas O. [1 ,2 ]
Page, Stephanie Cerceo [1 ,2 ]
Carroll, Cathy [3 ]
Kolb, Bryan [3 ]
机构
[1] Univ Maryland, Sch Med, Dept Pharmacol & Expt Therapeut, Baltimore, MD 21201 USA
[2] Univ Maryland, Sch Med, Program Neurosci, Baltimore, MD 21201 USA
[3] Univ Lethbridge, Canadian Ctr Behav Neurosci, Lethbridge, AB T1K 3M4, Canada
基金
加拿大健康研究院; 美国国家卫生研究院;
关键词
antipsychotic; dendrite; development; cortex; nucleus accumbens; plasticity; CA1 PYRAMIDAL CELLS; MEDIAL PREFRONTAL CORTEX; PITUITARY-ADRENAL AXIS; MESSENGER-RNA; ENVIRONMENTAL ENRICHMENT; ATYPICAL ANTIPSYCHOTICS; BEHAVIORAL ALTERATIONS; PLASMA-CONCENTRATIONS; MORPHOLOGICAL-CHANGES; SYNAPTIC PLASTICITY;
D O I
10.1002/syn.20715
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Exposure of the developing brain to a wide variety of drugs of abuse (e.g., stimulants, opioids, ethanol, etc.) can induce life-long changes in behavior and neural circuitry. However, the long-term effects of exposure to therapeutic, psychotropic drugs have only recently begun to be appreciated. Antipsychotic drugs are little studied in this regard. Here, we quantitatively analyzed dendritic architecture in adult mice treated with paradigmatic typical- (haloperidol) or atypical (olanzapine) antipsychotic drugs at developmental stages corresponding to fetal or fetal plus early childhood stages in humans. In layer 3 pyramidal cells of the medial and orbital prefrontal cortices and the parietal cortex and in spiny neurons of the core of the nucleus accumbens, both drugs induced significant changes (predominantly reductions) in the amount and complexity of dendritic arbor and the density of dendritic spines. The drug-induced plasticity of dendritic architecture suggests changes in patterns of neuronal connectivity in multiple brain regions that are likely to be functionally significant. Synapse 64:191-199, 2010. (C) 2009 Wiley-Liss, Inc.
引用
收藏
页码:191 / 199
页数:9
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