Metabolic responses and benefits of glucagon-like peptide-1 (GLP-1) receptor ligands

被引：27

作者：

Tanday, Neil ^{[1
]}

Flatt, Peter R. ^{[1
]}

Irwin, Nigel ^{[1
]}

机构：

[1] Ulster Univ, Diabet Res Grp, Coleraine, Londonderry, North Ireland

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2022年 / 179卷 / 04期

关键词：

diabetes; GLP‐ 1; incretin; obesity; DEPENDENT INSULINOTROPIC POLYPEPTIDE; TRIPLE-ACTING AGONIST; PANCREATIC BETA-CELLS; GLYCEMIC CONTROL; HYBRID PEPTIDE; CARDIOVASCULAR OUTCOMES; EXPRESSING CELLS; STIMULATES GLP-1; HEART-RATE; 7-36; AMIDE;

D O I：

10.1111/bph.15485

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Glucagon-like peptide-1 (GLP-1) is an incretin hormone that has undergone a revolutionary turnaround from discovery to clinically approved therapeutic. Rapid progress in drug design and formulation has led from initial development of short- and long-acting drugs suitable for daily or weekly parenteral administration, respectively, through to the most recent approval of an orally active GLP-1 agent. The current review outlines the biological action profile of GLP-1 including the various beneficial metabolic responses in pancreatic and extra-pancreatic tissues, including the gastrointestinal tract, liver, bone and kidney as well as the reproductive cardiovascular and CNS. We then briefly consider clinically approved GLP-1 receptor ligands and recent advances in this field. Given the sustained evolution in the area of GLP-1 drug development and excellent safety profile, as well as the plethora of metabolic benefits, clinical approval for use in diseases beyond diabetes and obesity is very much conceivable.

引用

页码：526 / 541

页数：16

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