Reconstructive outcome analysis of the impact of neoadjuvant chemotherapy on immediate breast reconstruction: a retrospective cross-sectional study

被引：9

作者：

Yang, Jia-Ruei ^{[1
]}

Kuo, Wen-Ling ^{[2
,3
]}

Yu, Chi-Chang ^{[2
,3
]}

Chen, Shin-Cheh ^{[2
,3
]}

Huang, Jung-Ju ^{[1
,3
,4
]}

机构：

[1] Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, Linkou Med Ctr, 5 Fu Hsing St, Taoyuan 33305, Taiwan

[2] Chang Gung Mem Hosp, Dept Gen Surg, Linkou Med Ctr, Taoyuan, Taiwan

[3] Chang Gung Univ, Coll Med, Taoyuan, Taiwan

[4] Chang Gung Mem Hosp, Ctr Tissue Engn, Linkou Med Ctr, Taoyuan, Taiwan

来源：

BMC CANCER | 2021年 / 21卷 / 01期

关键词：

Breast cancer; Immediate breast reconstruction; Mastectomy; Neoadjuvant chemotherapy; Surgical complication; Aesthetic outcome; SKIN-SPARING MASTECTOMY; POSTOPERATIVE COMPLICATIONS; CONSENSUS CONFERENCE; SURGICAL OUTCOMES; TERM OUTCOMES; RISK-FACTORS; CANCER; THERAPY; DETERMINANTS; RADIOTHERAPY;

D O I：

10.1186/s12885-021-08256-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundNeoadjuvant chemotherapy (NACT) was initially applied to locally advanced breast cancer to convert advanced lesions to an operable status. Currently, its application has been expanded to enhance overall oncological results, especially in patients with triple-negative or HER-2-positive breast cancer. With more NACT being applied, the role and impact of this approach on breast reconstruction needs to be determined. This study aimed to perform a complete reconstructive outcome analysis of patients receiving NACT who underwent immediate breast reconstruction.MethodsA retrospective review of a single reconstructive surgeon's immediate breast reconstructions performed from July 2008 to December 2018 was undertaken. The results were stratified by the use of NACT. Patient demographics, delivery of NACT, adjuvant treatment, incidence of surgical complications, and postoperative photographs were analyzed.ResultsA total of 269 patients were included. The mean follow-up was 46.3months. Forty-six out of 269 patients received NACT and were included in the NACT group. The other patients were included in the non-NACT group. When implant-based reconstruction was planned, the NACT group had a higher rate of two-stage tissue expander-implant reconstruction than direct-to-implant reconstruction (p<0.001). The requirement for postmastectomy radiotherapy was higher in the NACT group (p<0.001). The surgical complication rates were similar between groups after adjusting for confounding factors. The objective aesthetic outcomes assessed by 6 plastic surgeons were also similar between groups.ConclusionsImmediate breast reconstruction is a safe and reliable procedure, with an acceptable reconstructive complication rate and satisfactory aesthetic outcomes, for patients treated with NACT.

引用

页数：13

共 43 条

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