Steroid-responsive Nivolumab-induced Involuntary Movement with Anti-thyroid Antibodies

被引：5
作者：
Maetani, Yuta [1 ]
Nezu, Tomohisa [1 ]
Ueno, Hiroki [1 ]
Aoki, Shiro [1 ]
Hosomi, Naohisa [1 ]
Maruyama, Hirofumi [1 ]
机构：
[1] Hiroshima Univ, Fac Med, Grad Sch Biomed & Hlth Sci, Dept Clin Neurosci & Therapeut, Higashihiroshima, Hiroshima, Japan
来源：
INTERNAL MEDICINE | 2019年 / 58卷 / 24期
基金：
日本学术振兴会;
关键词：
nivolumab; immune related adverse event; DAT; SPECT; anti-thyroid antibody; Hashimoto's encephalopathy; AUTOANTIBODIES; PREVALENCE;
D O I：
10.2169/internalmedicine.3200-19
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We herein report a 68-year-old man with neurologic immune-related adverse events (irAEs) who exhibited nivolumab-induced steroid-responsive progressive ataxia, tremor, and anti-thyroid antibodies. His symptoms matched abnormalities on N-isopropyl-p-(123I)-iodoamphetamine single-photon emission computed tomography (SPECT) and dopamine transporter SPECT. Based on these clinical findings, we diagnosed the patient with a condition similar to the cerebellar type of Hashimoto's encephalopathy with nivolumab-induced antithyroid antibodies. Neurologic irAEs can be difficult to diagnose due to their varied clinical courses and lack of specific examinations. Therefore, a comprehensive approach, including assessments of autoantibodies and functional imaging, might be important for the diagnosis of neurologic irAEs.
引用
收藏
页码：3577 / 3581
页数：5
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