Anticancer activity studies of cubebin isolated from Piper cubeba and its synthetic derivatives

被引：22

作者：

Rajalekshmi, Dhanya S. ^{[1
,2
]}

Kabeer, Farha A. ^{[3
]}

Madhusoodhanan, Arya R. ^{[1
]}

Bahulayan, Arun K. ^{[4
]}

Prathapan, Remani ^{[3
]}

Prakasan, Nisha ^{[4
]}

Varughese, Sunil ^{[1
]}

Nair, Mangalam S. ^{[1
,2
]}

机构：

[1] Natl Inst Interdisciplinary Sci & Technol, CSIR, Chem Sci & Technol Div, Thiruvananthapuram 695019, Kerala, India

[2] NIIST, CSIR, Acad Sci & Innovat Res AcSIR, Thiruvananthapuram 695019, Kerala, India

[3] Reg Canc Ctr, Div Canc Res, Thiruvananthapuram, Kerala, India

[4] Natl Inst Interdisciplinary Sci & Technol, CSIR, Agroproc & Nat Prod Div, Thiruvananthapuram 695019, Kerala, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 07期

关键词：

Cubebin; Hinokinin; Amide derivatives; Anticancer activity; Morphological analysis; Apoptosis; NATURAL-PRODUCTS; DRUG DISCOVERY; PODOPHYLLOTOXIN; (-)-HINOKININ; LIGNAN; (-)-CUBEBIN; CYTOTOXICITY; GENOTOXICITY; INHIBITORS; CHEMISTRY;

D O I：

10.1016/j.bmcl.2016.02.041

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(-)-Cubebin, isolated from the seeds of Piper cubeba, and its five different types of derivatives (a total of 17), with varying functionalities, were tested for their in vitro anticancer activity against six human cancer cell lines (A549, K562, SiHa, KB, HCT116 and HT29) using MTT assay. Cubebin as well as its derivatives containing lactone and amide groups showed significant anticancer activity. In some of the tested cell lines, the amide derivatives showed higher activity. Morphological analysis indicated that these compounds act through apoptosis mediated pathway of cell death and we expect that these results will pave new paths in the development of novel anticancer agents by the derivatization of (-)-cubebin. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：1767 / 1771

页数：5

共 45 条

[1] Trypanosoma cruzi: evaluation of (-)-cubebin derivatives activity in the messenger RNAs processing [J].

Andrade e Silva, Marcio Luis ;

Barretto Cicarelli, Regina Maria ;

Pauletti, Patricia M. ;

Luz, Priscilla Paiva ;

Souza Rezende, Karen Cristina ;

Januario, Ana Helena ;

da Silva, Rosangela ;

Pereira, Ana Carolina ;

Bastos, Jairo Kenupp ;

de Albuquerque, Sergio ;

Magalhaes, Lizandra Guidi ;

Cunha, Wilson Roberto .

PARASITOLOGY RESEARCH, 2011, 109 (02) :445-451

[2]

[Anonymous], 2012, CANC FACTS FIG

[3] Chemopreventive Effects of (-)-Hinokinin against 1,2-Dimethylhydrazine-Induced Genotoxicity and Preneoplastic Lesions in Rat Colon [J].

Barbosa, Lilian C. ;

Furtado, Ricardo A. ;

Bertanha, Humberto C. C. ;

Tomazella, Iara M. ;

Costa, Eveline S. ;

Bastos, Jairo K. ;

Andrade e Silva, Marcio L. ;

Tavares, Denise C. .

JOURNAL OF NATURAL PRODUCTS, 2014, 77 (10) :2312-2315

[4] Anti-inflammatory activity of cubebin, a lignan from the leaves of Zanthoxyllum naranjillo Griseb [J].

Bastos, JK ;

Carvalho, JCT ;

de Souza, GHB ;

Pedrazzi, AHP ;

Sarti, SJ .

JOURNAL OF ETHNOPHARMACOLOGY, 2001, 75 (2-3) :279-282

[5] PRODUCTION AND METABOLISM OF LIGNANS BY THE HUMAN FECAL FLORA [J].

BORRIELLO, SP ;

SETCHELL, KDR ;

AXELSON, M ;

LAWSON, AM .

JOURNAL OF APPLIED BACTERIOLOGY, 1985, 58 (01) :37-43

[6] Analgesic activity of the lignans from Lychnophora ericoides [J].

Borsato, MLC ;

Grael, CFF ;

Souza, GEP ;

Lopes, NP .

PHYTOCHEMISTRY, 2000, 55 (07) :809-813

[7] The role of natural product chemistry in drug discovery [J].

Butler, MS .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (12) :2141-2153

[8] Cytotoxicity of extractives from Taiwania cryptomerioides heart-wood [J].

Chang, ST ;

Wang, DSY ;

Wu, CL ;

Shiah, SG ;

Kuo, YH ;

Chang, CJ .

PHYTOCHEMISTRY, 2000, 55 (03) :227-232

[9] Synthesis and Evaluation of New Podophyllotoxin Derivatives with in Vitro Anticancer Activity [J].

Cheng, Wei-Hua ;

Shang, Hai ;

Niu, Cong ;

Zhang, Zhong-Heng ;

Zhang, Li-Ming ;

Chen, Hong ;

Zou, Zhong-Mei .

MOLECULES, 2015, 20 (07) :12266-12279

[10]

Coimbra HdosS, 2004, B CHIM FARM, V143, P65

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