Gastric cancer: Basic aspects

被引：36

作者：

Duarte, Henrique O. ^{[1
,2
,3
]}

Gomes, Joana ^{[1
,2
]}

Machado, Jose C. ^{[1
,2
,4
]}

Reis, Celso A. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Porto, Inst Res & Innovat Hlth I3S, Porto, Portugal

[2] Univ Porto, IPATIMUP Inst Mol Pathol & Immunol, Porto, Portugal

[3] Univ Porto, ICBAS Inst Ciencias Biomed Abel Salazar, Porto, Portugal

[4] Univ Porto, Fac Med, Porto, Portugal

来源：

HELICOBACTER | 2018年 / 23卷

关键词：

gastric cancer; molecular subtyping; personalized therapy; RANDOMIZED PHASE-II; DOUBLE-BLIND; OPEN-LABEL; 2ND-LINE TREATMENT; ANTITUMOR-ACTIVITY; 1ST-LINE THERAPY; PLUS PACLITAXEL; CAPECITABINE; CHEMOTHERAPY; LAPATINIB;

D O I：

10.1111/hel.12523

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Despite major breakthroughs in the field of personalized medicine, gastric cancer (GC) remains a clinically challenging disease, characterized by scarce effective treatment options and the lack of reliable molecular tools for the prediction of patient outcome and response to therapy. The pronounced molecular heterogeneity that dictates the phenotypical aggressiveness of gastric neoplasms severely limits the antitumor efficacy of targeted agents brought to clinical trials, and constitutes a favorable setting for the emergence of refractory tumors exhibiting multidrug resistance. We will review the most recent advances in our understanding of GC biology, which are underlying the development and clinical testing of novel targeted therapeutic agents. We will also emphasize how their efficacy and acquired resistance relate to the aberrant molecular signatures that drive gastric malignancy.

引用

页数：6

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