The dual binding site of angiogenin and its inhibition mechanism: the crystal structure of the rat angiogenin-heparin complex

被引:9
作者
Yeo, Kwon Joo [1 ,2 ]
Hwang, Eunha [1 ,2 ]
Min, Kyong-Mi [3 ]
Jee, Jun-Goo [4 ]
Lee, Chung-Kyung [1 ]
Hwang, Kwang Yeon [2 ]
Jeon, Young Ho [5 ]
Chang, Soo-Ik [3 ]
Cheong, Hae-Kap [1 ]
机构
[1] Korea Basic Sci Inst, Div Magnet Resonance, Ochang 363883, Chungbuk, South Korea
[2] Korea Univ, Coll Life Sci & Biotechnol, Div Biotechnol, Seoul 136701, South Korea
[3] Chungbuk Natl Univ, Dept Biochem, Cheongju 362763, Chungbuk, South Korea
[4] Kyungpook Natl Univ, Coll Pharm, Pharmaceut Sci Res Inst, Taegu 702701, South Korea
[5] Korea Univ, Coll Pharm, Sejong 339700, South Korea
基金
新加坡国家研究基金会;
关键词
AMYOTROPHIC-LATERAL-SCLEROSIS; ENDOTHELIAL-CELLS; MONOCLONAL-ANTIBODY; TUMOR-GROWTH; IDENTIFICATION; PROLIFERATION; VARIANTS; OLIGOMER; DISEASE; GLUCOSE;
D O I
10.1039/c4cc05175k
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The heparin complex of rat angiogenin revealed that a heparin strand is fitted into a positively charged groove formed by the dual binding site of rat angiogenin, suggesting that cell adhesion to angiogenin is facilitated by its interaction with substrates on the cell surface and can be inhibited by heparin.
引用
收藏
页码:12966 / 12969
页数:4
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