The dual binding site of angiogenin and its inhibition mechanism: the crystal structure of the rat angiogenin-heparin complex

被引：9

作者：

Yeo, Kwon Joo ^{[1
,2
]}

Hwang, Eunha ^{[1
,2
]}

Min, Kyong-Mi ^{[3
]}

Jee, Jun-Goo ^{[4
]}

Lee, Chung-Kyung ^{[1
]}

Hwang, Kwang Yeon ^{[2
]}

Jeon, Young Ho ^{[5
]}

Chang, Soo-Ik ^{[3
]}

Cheong, Hae-Kap ^{[1
]}

机构：

[1] Korea Basic Sci Inst, Div Magnet Resonance, Ochang 363883, Chungbuk, South Korea

[2] Korea Univ, Coll Life Sci & Biotechnol, Div Biotechnol, Seoul 136701, South Korea

[3] Chungbuk Natl Univ, Dept Biochem, Cheongju 362763, Chungbuk, South Korea

[4] Kyungpook Natl Univ, Coll Pharm, Pharmaceut Sci Res Inst, Taegu 702701, South Korea

[5] Korea Univ, Coll Pharm, Sejong 339700, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 85期

基金：

新加坡国家研究基金会;

关键词：

AMYOTROPHIC-LATERAL-SCLEROSIS; ENDOTHELIAL-CELLS; MONOCLONAL-ANTIBODY; TUMOR-GROWTH; IDENTIFICATION; PROLIFERATION; VARIANTS; OLIGOMER; DISEASE; GLUCOSE;

D O I：

10.1039/c4cc05175k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The heparin complex of rat angiogenin revealed that a heparin strand is fitted into a positively charged groove formed by the dual binding site of rat angiogenin, suggesting that cell adhesion to angiogenin is facilitated by its interaction with substrates on the cell surface and can be inhibited by heparin.

引用

页码：12966 / 12969

页数：4

共 28 条

[1] SPECIFIC BINDING OF ANGIOGENIN TO CALF PULMONARY-ARTERY ENDOTHELIAL-CELLS [J].

BADET, J ;

SONCIN, F ;

GUITTON, JD ;

LAMARE, O ;

CARTWRIGHT, T ;

BARRITAULT, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (21) :8427-8431

[2] ANGIOGENIN ACTIVATES ENDOTHELIAL-CELL PHOSPHOLIPASE-C [J].

BICKNELL, R ;

VALLEE, BL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (16) :5961-5965

[3] Identification of novel Angiogenin (ANG) gene missense variants in German patients with amyotrophic lateral sclerosis [J].

Fernandez-Santiago, Ruben ;

Hoenig, Sabine ;

Lichtner, Peter ;

Sperfeld, Anne-Dorte ;

Sharma, Manu ;

Berg, Daniela ;

Weichenrieder, Oliver ;

Illig, Thomas ;

Eger, Katharina ;

Meyer, Thomas ;

Anneser, Johanna ;

Muench, Christoph ;

Zierz, Stephan ;

Gasser, Thomas ;

Ludolph, Albert .

JOURNAL OF NEUROLOGY, 2009, 256 (08) :1337-1342

[4] ISOLATION AND CHARACTERIZATION OF ANGIOGENIN, AN ANGIOGENIC PROTEIN FROM HUMAN CARCINOMA-CELLS [J].

FETT, JW ;

STRYDOM, DJ ;

LOBB, RR ;

ALDERMAN, EM ;

BETHUNE, JL ;

RIORDAN, JF ;

VALLEE, BL .

BIOCHEMISTRY, 1985, 24 (20) :5480-5486

[5] Mechanisms of action of angiogenin [J].

Gao, Xiangwei ;

Xu, Zhengping .

ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2008, 40 (07) :619-624

[6] ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis [J].

Greenway, MJ ;

Andersen, PM ;

Russ, C ;

Ennis, S ;

Cashman, S ;

Donaghy, C ;

Patterson, V ;

Swingler, R ;

Kieran, D ;

Prehn, J ;

Morrison, KE ;

Green, A ;

Acharya, KR ;

Brown, RH ;

Hardiman, O .

NATURE GENETICS, 2006, 38 (04) :411-413

[7] DUAL SITE MODEL FOR THE ORGANOGENIC ACTIVITY OF ANGIOGENIN [J].

HALLAHAN, TW ;

SHAPIRO, R ;

VALLEE, BL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (06) :2222-2226

[8] IMPORTANCE OF ASPARAGINE-61 AND ASPARAGINE-109 TO THE ANGIOGENIC ACTIVITY OF HUMAN ANGIOGENIN [J].

HALLAHAN, TW ;

SHAPIRO, R ;

STRYDOM, DJ ;

VALLEE, BL .

BIOCHEMISTRY, 1992, 31 (34) :8022-8029

[9] AN ANGIOGENIN-BINDING PROTEIN FROM ENDOTHELIAL-CELLS [J].

HU, GF ;

CHANG, SI ;

RIORDAN, JF ;

VALLEE, BL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (06) :2227-2231

[10] Synthesis of a Polyurea from a Glucose- or Mannose-Containing N-Alkyl Urea Peptoid Oligomer [J].

Huang, Yongshun ;

Taylor, Leeanne ;

Chen, Xiaoping ;

Ayres, Neil .

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2013, 51 (24) :5230-5238

← 1 2 3 →