A New Powerful Strategy for the Organocatalytic Asymmetric Construction of a Quaternary Carbon Stereogenic Center

被引：53
作者：
Inokoishi, Yogo [1 ]
Sasakura, Niiha [1 ]
Nakano, Keiji [1 ]
Ichikawa, Yoshiyasu [1 ]
Kotsuki, Hiyoshizo [1 ]
机构：
[1] Kochi Univ, Fac Sci, Lab Nat Prod Chem, Akebono, Kochi 7808520, Japan
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 07期
关键词：
ENANTIOSELECTIVE CONJUGATE ADDITION; MICHAEL ADDITION; KETONES; AMINE; ALDEHYDES;
D O I：
10.1021/ol100350w
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new method for chiral diamine-catalyzed Robinson-type annulation was developed to construct cyclohexenone derivatives bearing a quaternary carbon stereogenic center at the 4-position In high enantiomeric excess. This method was successfully applied to the short synthesis of (+)-sporochnol A.
引用
收藏
页码：1616 / 1619
页数：4
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