A New Powerful Strategy for the Organocatalytic Asymmetric Construction of a Quaternary Carbon Stereogenic Center

被引：53

作者：

Inokoishi, Yogo ^{[1
]}

Sasakura, Niiha ^{[1
]}

Nakano, Keiji ^{[1
]}

Ichikawa, Yoshiyasu ^{[1
]}

Kotsuki, Hiyoshizo ^{[1
]}

机构：

[1] Kochi Univ, Fac Sci, Lab Nat Prod Chem, Akebono, Kochi 7808520, Japan

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 07期

关键词：

ENANTIOSELECTIVE CONJUGATE ADDITION; MICHAEL ADDITION; KETONES; AMINE; ALDEHYDES;

D O I：

10.1021/ol100350w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for chiral diamine-catalyzed Robinson-type annulation was developed to construct cyclohexenone derivatives bearing a quaternary carbon stereogenic center at the 4-position In high enantiomeric excess. This method was successfully applied to the short synthesis of (+)-sporochnol A.

引用

页码：1616 / 1619

页数：4

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