Normalization of Low-Density Lipoprotein Receptor Expression in Receptor Defective Homozygous Familial Hypercholesterolemia by Inhibition of PCSK9 With Alirocumab

被引：24

作者：

Lambert, Gilles ^{[1
]}

Chatelais, Mathias ^{[1
]}

Petrides, Francine ^{[1
]}

Passard, Maxime ^{[1
]}

Thedrez, Aurelie ^{[1
]}

Rye, Kerry-Anne ^{[1
]}

Schwahn, Uwe ^{[1
]}

Gusarova, Viktoria ^{[1
]}

Blom, Dirk J. ^{[1
]}

Sasiela, William ^{[1
]}

Marais, A. David ^{[1
]}

机构：

[1] CHU Hotel Dieu, UMR PhAN HNB1, F-44000 Nantes, France

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2014年 / 64卷 / 21期

关键词：

MONOCLONAL-ANTIBODY;

D O I：

10.1016/j.jacc.2014.07.995

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：2299 / 2300

页数：2

共 4 条

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[2] Elevated Plasma PCSK9 Level Is Equally Detrimental for Patients With Nonfamilial Hypercholesterolemia and Heterozygous Familial Hypercholesterolemia, Irrespective of Low-Density Lipoprotein Receptor Defects [J].

Lambert, Gilles ;

Petrides, Francine ;

Chatelais, Mathias ;

Blom, Dirk J. ;

Choque, Benjamin ;

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Wong, Gida ;

Rye, Kerry-Anne ;

Hooper, Amanda J. ;

Burnett, John R. ;

Barter, Philip J. ;

Marais, A. David .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2014, 63 (22) :2365-2373

[3] Reduction of Low-Density Lipoprotein Cholesterol by Monoclonal Antibody Inhibition of PCSK9 [J].

Stein, Evan A. ;

Raal, Frederick .

ANNUAL REVIEW OF MEDICINE, VOL 65, 2014, 65 :417-431

[4] Effect of the Proprotein Convertase Subtilisin/Kexin 9 Monoclonal Antibody, AMG 145, in Homozygous Familial Hypercholesterolemia [J].

Stein, Evan A. ;

Honarpour, Narimon ;

Wasserman, Scott M. ;

Xu, Feng ;

Scott, Rob ;

Raal, Frederick J. .

CIRCULATION, 2013, 128 (19) :2113-2120

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