High-speed Intravascular Photoacoustic Imaging of Lipid-laden Atherosclerotic Plaque Enabled by a 2-kHz Barium Nitrite Raman Laser

被引：102

作者：

Wang, Pu ^{[1
]}

Ma, Teng ^{[2
]}

Slipchenko, Mikhail N. ^{[1
,3
]}

Liang, Shanshan ^{[4
,5
,6
]}

Hui, Jie ^{[7
]}

Shung, K. Kirk ^{[2
]}

Roy, Sukesh ^{[3
]}

Sturek, Michael ^{[8
]}

Zhou, Qifa ^{[2
]}

Chen, Zhongping ^{[4
]}

Cheng, Ji-Xin ^{[1
]}

机构：

[1] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47906 USA

[2] Univ So Calif, Dept Biomed Engn, NIH Ultrason Transducer Resource Ctr, Los Angeles, CA 90089 USA

[3] Spectral Energy LLC, Dayton, OH 45431 USA

[4] Univ Calif Irvine, Dept Biomed Engn, Irvine, CA 92697 USA

[5] Univ Calif Irvine, Beckman Laser Inst, Irvine, CA 92612 USA

[6] Univ Calif Irvine, Edwards Lifesci Ctr Adv Cardiovasc Technol, Irvine, CA 92697 USA

[7] Purdue Univ, Dept Phys, W Lafayette, IN 47906 USA

[8] Indiana Univ Sch Med, Dept Cellular & Integrat Physiol, Indianapolis, IN 46202 USA

来源：

SCIENTIFIC REPORTS | 2014年 / 4卷

关键词：

OPTICAL COHERENCE TOMOGRAPHY; DEEP TISSUE; CORONARY; ULTRASOUND; INFLAMMATION; TIME; IVUS;

D O I：

10.1038/srep06889

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Lipid deposition inside the arterial wall is a key indicator of plaque vulnerability. An intravascular photoacoustic (IVPA) catheter is considered a promising device for quantifying the amount of lipid inside the arterial wall. Thus far, IVPA systems suffered from slow imaging speed (similar to 50 s per frame) due to the lack of a suitable laser source for high-speed excitation of molecular overtone vibrations. Here, we report an improvement in IVPA imaging speed by two orders of magnitude, to 1.0 s per frame, enabled by a custom-built, 2-kHz master oscillator power amplifier (MOPA)-pumped, barium nitrite [Ba(NO3)(2)] Raman laser. This advancement narrows the gap in translating the IVPA technology to the clinical setting.

引用

页数：7

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