Synthesis of monomethylated dioscin derivatives and their antitumor activities

被引：48

作者：

Li, M

Han, XW ^{[1
]}

Yu, B

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalyst, Dalian 116023, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

来源：

CARBOHYDRATE RESEARCH | 2003年 / 338卷 / 02期

基金：

中国国家自然科学基金;

关键词：

dioscin; methylation; synthesis; antitumor;

D O I：

10.1016/S0008-6215(02)00443-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

All possible eight monomethylated dioscin derivatives (1-8) were synthesized. Their inhibitory activities against P388 and A-549 cells were determined, and the results indicate that six of the eight hydroxyls of dioscin are the 'key polar groupings' for tumor inhibitory activities. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：117 / 121

页数：5

共 31 条

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