18F-FDG-PET/CT VERSUS PANENDOSCOPY FOR THE DETECTION OF SYNCHRONOUS SECOND PRIMARY TUMORS IN PATIENTS WITH HEAD AND NECK SQUAMOUS CELL CARCINOMA

被引：63

作者：

Haerle, Stephan K. ^{[1
]}

Strobel, Klaus ^{[2
]}

Hany, Thomas F. ^{[2
]}

Sidler, Daniel ^{[1
]}

Stoeckli, Sandro J. ^{[1
,3
]}

机构：

[1] Univ Zurich Hosp, Dept Otorhinolaryngol Head & Neck Surg, CH-8091 Zurich, Switzerland

[2] Univ Zurich Hosp, Dept Nucl Med, CH-8091 Zurich, Switzerland

[3] Kantonsspital, Dept Otorhinolaryngol Head & Neck Surg, St Gallen, Switzerland

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2010年 / 32卷 / 03期

关键词：

F-18-FDG-PET/CT; panendoscopy; initial staging; second primary tumors; head and neck; POSITRON-EMISSION-TOMOGRAPHY; ROUTINE PANENDOSCOPY; CANCER; PET; THERAPY; IMPACT;

D O I：

10.1002/hed.21184

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. This study assesses the additional value of F-18-fluoro-2-deoxy-D-glucose positron emission tomography/CT (F-18-FDG-PET/CT) with respect to synchronous primaries in patients undergoing panendoscopy for staging of head and neck squamous cell carcinoma. Methods. In all, 311 patients underwent both modalities. Cytology, histology, and/or clinical/imaging follow-up served as reference standard. Results. The prevalence of second primary tumors detected by panendoscopy was 4.5%, compared with 6.1% detected by F-18-FDG-PET/CT. The sensitivity for panendoscopy was 74%, the specificity was 99.7%, the positive predictive value (PPV) was 93%, and the negative predictive value (NPV) was 98%. The sensitivity for F-18-FDG-PET/CT was 100%, the specificity was 95.7%, the PPV was 59%, and the NPV was 100%. Conclusions, 18F-FDG-PET/CT is superior to panendoscopy. With a negative F-18-FDG-PFT/CT, the extent of endoscopy can be reduced to the area of the primary tumor. Due to the costs, F-18-FDG-PET/CT is recommended only in advanced disease to assess potential distant disease. In early-stage cancer, panendoscopy is accurate enough to rule out secondary tumors. (C) 2009 Wiley Periodicals, Inc. Head Neck 32: 319325, 2010

引用

页码：319 / 325

页数：7

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