Reactive oxygen species produced in mitochondria are involved in age-dependent changes of hematopoietic and mesenchymal progenitor cells in mice. A study with the novel mitochondria-targeted antioxidant SkQ1

被引：20

作者：

Shipounova, I. N. ^{[3
]}

Svinareva, D. A. ^{[3
]}

Petrova, T. V. ^{[3
]}

Lyamzaev, K. G. ^{[1
,2
]}

Chernyak, B. V. ^{[1
,2
]}

Drize, N. I. ^{[3
]}

Skulachev, V. P. ^{[1
,2
]}

机构：

[1] Moscow MV Lomonosov State Univ, AN Belozersky Inst Physicochem Biol, Moscow, Russia

[2] Moscow MV Lomonosov State Univ, Mitoengn Ctr, Moscow, Russia

[3] Russian Acad Med Sci, Natl Hematol Res Ctr, Moscow 109801, Russia

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2010年 / 131卷 / 06期

基金：

俄罗斯基础研究基金会;

关键词：

Aging; Blood; SkQ1; Hematopoietic and mesenchymal stem cells; CFU-C; CFU-F; STEM-CELLS; BONE-MARROW; PLASTOQUINONE DERIVATIVES; INTERRUPT EXECUTION; STROMAL CELLS; TOOLS; SENESCENCE; EXPANSION; APOPTOSIS; THYMUS;

D O I：

10.1016/j.mad.2010.06.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lifelong treatment of mice with the effective mitochondria-targeted antioxidant SkQ1 [10-(6'-plastoquinonyl) decyltriphenylphosphonium] does not affect hematopoietic stem cells (HSC) and more differentiated hematopoietic progenitors but significantly decelerates age-dependent changes in peripheral blood. During the first 13 months, SkQ1 (0.9 or 28.8 nmol/kg day) prevents age-dependent myeloid shift (increase in the proportion of granulocytes and decrease in the proportion of lymphocytes). During the next year of treatment the effect disappears, and the hemogram of 2-year-old treated mice does not differ from the control. The number of mesenchymal stem cells (MSC) in the bone marrow does not change during 2 years of treatment with SkQ1, but the concentration of MSC progeny fibroblast colony-forming units (CFU-F) increases with dose of SkQ1. The concentration of CFU-F after 1 and 2 years treatment with SkQ1 is twice higher than in young mice Our data indicate that the stromal environment of hematopoietic cells could be the primary target of age-dependent changes mediated by reactive oxygen species produced in mitochondria. The anti-aging effects of SkQ1 described here are in perfect agreement with the inhibitory effects of this antioxidant on aging observed in the other models. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：415 / 421

页数：7

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