Pyrrolidinohydroquinazolines -: a novel class of CCR3 modulators

被引：37

作者：

Anderskewitz, R ^{[1
]}

Bauer, R ^{[1
]}

Bodenbach, G ^{[1
]}

Gester, D ^{[1
]}

Gramlich, B ^{[1
]}

Morschhäuser, G ^{[1
]}

Birke, FW ^{[1
]}

机构：

[1] Boehringer Ingelheim Pharma GmbH & Co KG, D-88397 Biberach Riss, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 03期

关键词：

CCR3; eotaxin; antagonist; agonist;

D O I：

10.1016/j.bmcl.2004.11.039

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel class of CCR3 modulators is described. Starting with lead compound 4a (K-i: 110 nM), which turned out to be all antagonist of eotaxin at the CCR3 receptor, further optimization led to compound 8b (K-i: 28 nM), which surprisingly proved to be an agonist. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：669 / 673

页数：5

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