Synergistic activity of ceftazidime-avibactam and aztreonam against serine and metallo-β-lactamase-producing gram-negative pathogens

被引：88

作者：

Wenzler, Eric ^{[1
]}

Deraedt, Matthew F. ^{[1
]}

Harrington, Amanda T. ^{[2
]}

Danizger, Larry H. ^{[1
,3
]}

机构：

[1] Univ Illinois, Coll Pharm, Chicago, IL 60607 USA

[2] Univ Illinois, Dept Pathol, Chicago, IL USA

[3] Univ Illinois, Coll Med, Chicago, IL USA

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2017年 / 88卷 / 04期

关键词：

Aztreonam; Ceftazidime; Avibactam; Synergy; Etest; beta-Lactamase; Carbapenemase; ANTIMICROBIAL SYNERGY;

D O I：

10.1016/j.diagmicrobio.2017.05.009

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

This study assessed the in vitro synergy between ceftazidime, aztreonam, and ceftazidime-avibactam against serine and metallo-beta-lactamase (MBL)-producing pathogens via the Etest MIC:MIC ratio and Agar-Etest synergy methods. The combination of aztreonam and ceftazidime-avibactam was synergistic against all Enterobacteriaceae. None of the tested combinations were consistently synergistic against IMP -producing P. aeruginosa. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：352 / 354

页数：3

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