Treatment of Chronic Lymphocytic Leukemia With Genetically Targeted Autologous T Cells: Case Report of an Unforeseen Adverse Event in a Phase I Clinical Trial

被引:317
作者
Brentjens, Renier [1 ]
Yeh, Raymond [1 ]
Bernal, Yvette [1 ]
Riviere, Isabelle [1 ]
Sadelain, Michel [1 ]
机构
[1] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
关键词
TUMORS;
D O I
10.1038/mt.2010.31
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
引用
收藏
页码:666 / 668
页数:3
相关论文
共 6 条
[1]   Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts [J].
Brentjens, Renier J. ;
Santos, Elmer ;
Nikhamin, Yan ;
Yeh, Raymond ;
Matsushita, Maiko ;
La Perle, Krista ;
Quintas-Cardama, Alfonso ;
Larson, Steven M. ;
Sadelain, Michel .
CLINICAL CANCER RESEARCH, 2007, 13 (18) :5426-5435
[2]   Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15 [J].
Brentjens, RJ ;
Latouche, JB ;
Santos, E ;
Marti, F ;
Gong, MC ;
Lyddane, C ;
King, PD ;
Larson, S ;
Weiss, M ;
Rivière, I ;
Sadelain, M .
NATURE MEDICINE, 2003, 9 (03) :279-286
[3]   Manufacturing Validation of Biologically Functional T Cells Targeted to CD19 Antigen for Autologous Adoptive Cell Therapy [J].
Hollyman, Daniel ;
Stefanski, Jolanta ;
Przybylowski, Mark ;
Bartido, Shirley ;
Borquez-Ojeda, Oriana ;
Taylor, Clare ;
Yeh, Raymond ;
Capacio, Vanessa ;
Olszewska, Malgorzata ;
Hosey, James ;
Sadelain, Michel ;
Brentjens, Renier J. ;
Riviere, Isabelle .
JOURNAL OF IMMUNOTHERAPY, 2009, 32 (02) :169-180
[4]   Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ/CD28 receptor [J].
Maher, J ;
Brentjens, RJ ;
Gunset, G ;
Rivière, I ;
Sadelain, M .
NATURE BIOTECHNOLOGY, 2002, 20 (01) :70-75
[5]   Targeting tumours with genetically enhanced T lymphocytes [J].
Sadelain, M ;
Rivière, I ;
Brentjens, R .
NATURE REVIEWS CANCER, 2003, 3 (01) :35-45
[6]   The promise and potential pitfalls of chimeric antigen receptors [J].
Sadelain, Michel ;
Brentjens, Renier ;
Riviere, Isabelle .
CURRENT OPINION IN IMMUNOLOGY, 2009, 21 (02) :215-223