Relationship between dendritic cells and the D-fraction-induced Th-1 dominant response in BALB/c tumor-bearing mice

被引：48

作者：

Harada, N ^{[1
]}

Kodama, N ^{[1
]}

Nanba, H ^{[1
]}

机构：

[1] Kobe Pharmaceut Univ, Dept Microbial Chem, Higashinada Ku, Kobe, Hyogo 6588558, Japan

来源：

CANCER LETTERS | 2003年 / 192卷 / 02期

关键词：

dendritic cells; polysaccharide; Th-1; dominance;

D O I：

10.1016/S0304-3835(02)00716-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Dendritic cells (DCs) are known to not only induce the activation of T cells, but are also associated with the differentiation of T cells. The D-fraction, a P-glucan extracted from maitake (Grifola frondosa) which expresses anti-tumor effects by establishing a helper (Th)-1 dominance in BALB/c mice, enhanced IL-12p70 production by DCs, when the ratio of CD8alpha(+) DCs to CD8alpha(-) DCs increased. In addition, examination of the tumor rejection effect of D-fraction-stimulated DCs loaded with tumor antigen revealed that tumor growth is inhibited completely by activating CD4(+) T cells and CD8(+) T cells. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：181 / 187

页数：7

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