The Direct-Acting Antivirals for Hepatitis C Virus and the Risk for Hepatocellular Carcinoma

被引:6
作者
Chinchilla-Lopez, Paulina [1 ]
Qi, Xingshun [2 ]
Yoshida, Eric M. [3 ,4 ]
Mendez-Sanchez, Nahum [1 ]
机构
[1] Med Sur Clin & Fdn, Liver Res Unit, Puente Piedra 150, Mexico City 14050, DF, Mexico
[2] Gen Hosp Shenyang Mil Area, Dept Gastroenterol, Shenyang, Peoples R China
[3] Univ British Columbia, Vancouver, BC, Canada
[4] Vancouver Gen Hosp, Div Gastroenterol, Vancouver, BC, Canada
关键词
Liver; Cancer; Drugs; Hepatitis; SUSTAINED VIROLOGICAL RESPONSE; RECURRENCE; HCC;
D O I
10.5604/16652681.1235473
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The increase of incidences of Hepatocellular Carcinoma (HCC) will continue in the next decades. The therapies about hepatitis C infection has been questioned as a risk factor. Some authors emphasized that sustained virologic response (SVR) with interferon based therapy reduced the risk of developing HCC. In contrast, some publications that to suggest an increasing risk of HCC in patients treated with Direct-Acting Antivirals (DAA). Whether these therapies are associated with an increased risk of HCC remains to be studied and continued long-term observational studies will be needed. The goal in HCV care needs to go beyond merely achieving an SVR.
引用
收藏
页码:328 / 330
页数:3
相关论文
共 11 条
[1]   Direct antiviral agents and risk for HCC early recurrence: Much ado about nothing [J].
Camma, Calogero ;
Cabibbo, Giuseppe ;
Craxi, Antonio .
JOURNAL OF HEPATOLOGY, 2016, 65 (04) :861-862
[2]  
Conti F, 2016, J HEPATOL, P30303
[3]   Projecting future complications of chronic hepatitis C in the United States [J].
Davis, GL ;
Albright, JE ;
Cook, SF ;
Rosenberg, DM .
LIVER TRANSPLANTATION, 2003, 9 (04) :331-338
[4]   Mortality in hepatitis C patients who achieve a sustained viral response compared to the general population [J].
Innes, Hamish ;
McDonald, Scott ;
Hayes, Peter ;
Dillon, John F. ;
Allen, Sam ;
Goldberg, David ;
Mills, Peter R. ;
Barclay, Stephen T. ;
Wilks, David ;
Valerio, Heather ;
Fox, Ray ;
Bhattacharyya, Diptendu ;
Kennedy, Nicholas ;
Morris, Judith ;
Fraser, Andrew ;
Stanley, Adrian ;
Bramley, Peter ;
Hutchinson, Sharon J. .
JOURNAL OF HEPATOLOGY, 2017, 66 (01) :19-27
[5]   American Gastroenterological Association Institute Clinical Practice Update-Expert Review: Care of Patients Who Have Achieved a Sustained Virologic Response After Antiviral Therapy for Chronic Hepatitis C Infection [J].
Jacobson, Ira M. ;
Lim, Joseph K. ;
Fried, Michael W. .
GASTROENTEROLOGY, 2017, 152 (06) :1578-1587
[6]   Long-term effect of sustained virological response on hepatocellular carcinoma in patients with hepatitis C in Canada [J].
Janjua, Naveed Z. ;
Chong, Mei ;
Kuo, Margot ;
Woods, Ryan ;
Wong, Jason ;
Yoshida, Eric M. ;
Sherman, Morris ;
Butt, Zahid A. ;
Samji, Hasina ;
Cook, Darrel ;
Yu, Amanda ;
Alvarez, Maria ;
Tyndall, Mark ;
Krajden, Mel .
JOURNAL OF HEPATOLOGY, 2017, 66 (03) :504-513
[7]  
Mendez-Sanchez Nahum, 2005, Ann Hepatol, V4, P52
[8]   Hepatocellular carcinoma decreases the chance of successful hepatitis C virus therapy with direct-acting antivirals [J].
Prenner, Stacey B. ;
VanWagner, Lisa B. ;
Flamm, Steven L. ;
Salem, Riad ;
Lewandowski, Robert J. ;
Kulik, Laura .
JOURNAL OF HEPATOLOGY, 2017, 66 (06) :1173-1181
[9]   Unexpected high rate of early tumor recurrence in patients with HCV-related HCC undergoing interferon-free therapy [J].
Reig, Maria ;
Marino, Zoe ;
Perello, Christie ;
Inarrairaegui, Mercedes ;
Ribeiro, Andrea ;
Lens, Sabela ;
Diaz, Alba ;
Vilana, Ramon ;
Darnell, Anna ;
Varela, Maria ;
Sangro, Bruno ;
Luis Calleja, Jose ;
Forns, Xavier ;
Bruix, Jordi .
JOURNAL OF HEPATOLOGY, 2016, 65 (04) :719-726
[10]   Association Between Sustained Virological Response and All-Cause Mortality Among Patients With Chronic Hepatitis C and Advanced Hepatic Fibrosis [J].
van der Meer, Adriaan J. ;
Veldt, Bart J. ;
Feld, Jordan J. ;
Wedemeyer, Heiner ;
Dufour, Jean-Francois ;
Lammert, Frank ;
Duarte-Rojo, Andres ;
Heathcote, E. Jenny ;
Manns, Michael P. ;
Kuske, Lorenz ;
Zeuzem, Stefan ;
Hofmann, W. Peter ;
de Knegt, Robert J. ;
Hansen, Bettina E. ;
Janssen, Harry L. A. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2012, 308 (24) :2584-2593